COCAINE AXD BARIUM o.V) 



Cocaine often causes Cheyne-Stokes respiration. Can 

 yon produce this in your animal ? (What other drugs often 

 give this form of breathing f) 



What action has cocaine on the intraocular pressure? 

 Does your experiment demonstrate this! Will the method 

 of application of the drug affect the result ! If so drop 

 some cocaine solution into the eye from which you are 

 making your records. Does this have any effect! Will it 

 be absorbed! Watch the pupils. 



What action have small doses of cocaine on the blood- 

 pressure! Is this action increased by larger doses! What 

 is the treatment for cocaine poisoning! Would you ad- 

 vise giving a drug to lower the blood-pressure in this con- 

 dition! Would the presence of an anesthetic in your animal 

 make any profound change in the pharmacological action 

 of cocaine ! Have you used pure drugs ? What are your 

 conclusions! 



Wait a reasonable time for Cheyne-Stokes respiration 

 to develop. Then empty out the cocaine solution and place 

 barium chloride solution (one-half per cent) in the burette. 

 Adjust all writing points and take a normal record. Inject 

 four cubic centimeters (dog) of barium solution (five cubic 

 centimeters if the dog weighs ten kilos or more) and get a 

 record showing the action of the drug. How is the intestine 

 affected! The intraocular pressure? 



Again empty out the barium and refill the burette with 

 novocaine solution (one cubic centimeter equals five milli- 

 grams). Get the animal into as good condition as possible 

 (give adrenaline if necessary) and then take a normal rec- 

 ord. Inject one-half cubic centimeter of novocaine solution 

 and compare the action with that of cocaine. Inject a 

 larger dose. Which is more toxic, cocaine or novocaine! 

 (Your animal may not be nearly so sensitive now to small 

 doses of drugs as it was in the beginning.) 



Empty out the novocaine and refill the burette with co- 

 caine solution. Adjust all writing points and inject a large 



