ERGAM1NE, ADRENALINE, TYRAMINE 369 



Now inject cautiously in small repeated doses several 

 cubic centimeters of ergotoxine. How is the blood-pressure 

 affected? Examine the pupils from time to time and note 

 any change. Stimulate one vagus nerve and observe the 

 effect on the corresponding pupil and the heart. Does the 

 blcod-pressure fall to a low level and remain there? Does 

 the ergotoxine now fail to raise the blood-pressure (in the 

 same sized dose as that first given) ? Get the animal into as 

 gocd condition as possible and inject one cubic centimeter 

 cf adrenaline. Do you get a marked rise in blood-pressure'? 

 Does the uterus react? Was the dose large enough? Ex- 

 plain your results in detail. What structures have been in- 

 volved and how are they affected? Do your results cor- 

 respond with those described in the literature? 



Empty out the ergamine, fill the burette with one-half per 

 cent barium chloride and inject five cubic centimeters (dog). 

 Do you get a rise in blood-pressure or a contraction of the 

 uterus? On what structures does the barium act? Have 

 these been affected by the other drugs! 



Kill the animal with barium. After death dissect out the 

 thoracic duct in the neck and place a thread around it. (See 

 Figs. 302 and 319.) Also dissect out the left pulmonary 

 artery (Figs. 274, 275, 276, and 277). 



EXPERIMENT CIV. 



Ergamine, Adrenaline, Tyramine, (Codeine or Heroine). 

 (Dog: Blood-pressure, Pulmonary Blood-pressure, 



Respiration.) 



1. The dog should weigh at least eight or ten kiloG. It is 

 advisable to give a small dose of chloretone. Arrange for 

 recording blood-pressure and set up the two manometers 

 (one for the pulmonary pressure) as shown in Fig. 273. 

 Read over the directions for Experiment LXXVII, p. 310, 

 carefully, and prepare to follow out the technic given there 



