DIGITOXIN, STROPHANTHIN, NITROGLYCERINE 415 



1902, p. 417 ; Vanderkleecl and Pittenger : Journal of the 

 American Pharmaceutical Association, 1913, xi, p. 558; 

 Edmunds: Hygienic Laboratory Bulletin No. 48; Hatcher: 

 Journal of the American Medical Association, 1910, ii, p. 

 1697 ; U. S. P. ix, p. 606 ; Pittenger and Vanderkleed : Jour- 

 nal of the American Pharmaceutical Association, 1915.) 



EXPERIMENT CXXIX. 



Digitoxin, Strophanthin, Nitroglycerine. (Dog: Pulmonary 

 Blood-pressure, Carotid Pressure.) 



1. Arrange a dog for recording carotid and pulmonary 

 blood-pressure tracings according to the method learned 

 previously. Place digit oxin solution (five cubic centimeters 

 equal one milligram) in one injecting burette and strophan- 

 thin solution (five cubic centimeters equal one milligram) 

 in the other. 



When all adjustments are ready take a short normal rec- 

 ord and inject one cubic centimeter of digitoxin. Wait for 

 the animal to recover. When the records return approxi- 

 mately to normal inject one cubic centimeter of strophan- 

 thin. Do you get satisfactory records from both drugs? 

 How is the pulmonary blood pressure affected ? Does this 

 correspond with the systemic circulation? Do the two 

 drugs act alike on the pulmonary vessels! Which is the 

 more powerful! If these doses were too small to produce 

 any noticeable result give another larger injection of each 

 one to secure satisfactory tracings. 



Now empty the digitoxin out and fill the burette (or, bet- 

 ter, connect a third burette to a neck vein at the start) with 

 one-half per cent nitroglycerine. Take a normal quickly 

 and then inject one cubic centimeter of the nitroglycerine 

 solution. Do you get a satisfactory record ? If so how is 

 the pulmonary pressure affected! Does this have any 

 special clinical significance? How doe?' it compare with 

 digitoxin ? 



