ACOISTITINE AND VERATRINE 433 



this hold in the case of the frog ! Watch for the sudden ap- 

 pearance of irregular heart beats, extra systoles, etc. In 

 what chambers are these first developed? Can yon get 

 satisfactory records of the heart movements when the rate 

 is exceedingly fast? Watch for the sudden development 

 of delirium cordis. What happens to the blood-pressure 

 when this occurs ? After the heart begins to fibrillate stimu- 

 late the vagi and see if yon can stop the fibrillation. What 

 conclusions can yon draw? Feel of the heart and describe 

 the nature of the fibrillary contractions. 



EXPERIMENT CXXXVI1I. 

 Aconitine. (Student: Local Action.) 



1. Saturate a piece of filter paper one-fourth inch square 

 with a solution of aconitine (ten cubic centimeters equal one 

 milligram) and place the filter paper on the tongue. Do 

 not swallow any of the solution. After a little while re- 

 move the paper and note the sensation produced on the 

 tongue. What conclusions can you draw? (If the solution 

 was too weak a stronger one may be used.) 



EXPERIMENT CXXXIX. 

 Veratrine. (Frog: General Action.) 



1. Destroy the cerebrum only of a frog, wait for the shock 

 to disappear and then inject one cubic centimeter of vera- 

 trine sulphate solution (ten cubic centimeters equal one 

 milligram) into the dorsal lymph sac. Place the animal on 

 a table and wait a little while for the drug to be absorbed. 

 From time to time touch the animal gently and get it to 

 jump. Do you notice anything unusual about its move- 

 ments? Does it have trouble in extending or relaxing its 

 muscles! Does it have spontaneous convulsions ? Examine 

 the skin to see if there is an increased cutaneous secre- 



