450 



EXPERIMENTAL PHARMACOLOGY 



unie! Is it possible to determine the action of such drugs 

 as antipyrine or /8-tetrahydronaphthylamine on the heat 

 regulating mechanism in a brief interval of time, e. g., in 

 ten minutes! On what do you base your conclusions? 



From time to time inject more antipyrine and see what 

 later actions the drug has. Further injections of /3-tetra- 



Fix. 351. Tracine showine the action of pilocaroine and /3-tetrahydronaphthylamine hydro- 

 chloride on the bronchioles and blood-pressure in a spinal dog. 



hydronaphthylamine may also be made to get satisfactory 

 tracings. Kill the animal with antipyrine. AVhat symptoms 

 are produced and what is the immediate cause of death? 



/8-tetrahydronaphthylamine belongs to a class of drugs 

 to which the name "sympatho-mimetic" has been applied. 

 Adrenaline is the best known member of this group. These 

 drugs act on one or more parts of the involuntary nervous 

 system (see Fig. 318). 



