ANTIPYRETICS 451 



EXPERIMENT CLIII. 



Antipyrine, Peptone. (Two Rabbits: Temperature 



Regulation.) 



1. Four hours before the class meets administer hypo- 

 dermically to each of two rabbits (one for a control) one- 

 tenth of a gram per kilogram of weight of Witte 's peptone 

 (in twenty per cent solution). Record the temperature of 

 both rabbits and then give one by stomach one-tenth gram 

 per kilogram of weight of antipyrine. Record the tem- 

 perature of each animal at fifteen minute intervals, and de- 

 termine whether or not the temperature is affected by the 

 antipyrine. 



EXPERIMENT CLIV. 



Quinine, Peptone. (Two Rabbits: Temperature 

 Regulation.) 



1. Repeat the above experiment but substitute quinine 

 hydrochloride (one-tenth gram per kilo) for the antipy- 

 rine. Does this affect the temperature in any way? Dis- 

 cuss the manner of action of antipyrine and of quinine on 

 the heat regulating meclianism and on the reduction of 

 fever temperature. 



EXPERIMENT CLV. 



Phenacetine, Acetanilide or Aspirin (Acetylsalicylic Acid). 

 (Fevered Animal: Temperature.) 



1. Watch the stock of animals during the period when 

 the antipyretics are being studied and if an animal be- 

 comes ill with a rise in temperature then administer to it 

 by stomach one-tenth gram per kilogram of weight of phe- 

 nacetine, acetanilide, or aspirin. Record the temperature 

 at fifteen minute intervals and see if any change occurs. 



