/8-TETRAHYDRONAPHTHYLAM1XE AND P1LOCARPINE 453 



EXPERBIENT CLVIII. 



/8-tetrahydronaphthylamine Hydrochloride, Pilocarpine. 



(Dog: Oxygen Consumption, Blood-pressure, 



Respiration.) 



1. Arrange a dog (eight or ten kilos) for recording oxy- 

 gen consumption, blood-pressure and respiration. (Give a 

 small dose of chloretone.) The injecting burettes contain 

 /3-tetrahydronaphthylamine hydrochloride (one cubic cen- 

 timeter equals five milligrams) and pilocarpine (one cubic 

 centimeter equals one milligram.) 



"When all adjustments are made take a normal record 

 (showing at least two notches of the oxygen record). Then 

 inject two cubic centimeters of the /?-tetrahydronaphthyla- 

 mine (watch the pupils) and record the results. How is 

 the rate of oxygen consumption affected ? Wait for the 

 drug to act and see if all records return again to normal. 



Then give one cubic centimeter of pilocarpine. Watch 

 the rate and depth of the respiratory movements as the 

 drug begins to act and wait a little while for this to develop. 

 The action of pilocarpine is rather prolonged and may in- 

 crease in intensity for about one minute, or in some organs 

 for even a longer period. Is there any difficulty in either 

 expiration or inspiration ? What did the oxygen record 

 show just after the pilocarpine was injected? How do you 

 account for this? What kind of an effect on the oxygen 

 record would a drug show if it acted in a manner exactly 

 the opposite to that of pilocarpine? 



When the pilocarpine action becomes well marked (give 

 another one cubic centimeter if absolutely necessary) then 

 inject a dose (probably three or four cubic centimeters of 

 /3-tetrahydronaphthylamine estimate a good sized dose by 

 your previous result) and see how this drug counteracts 

 the pilocarpine. How is the oxygen record affected? How 

 do you account for this? Do you know of any other drug 

 that resembles /3-tetrahydronaphthylamine in action? 



