454 EXPERIMENTAL PHARMACOLOGY 



Record the temperature of the animal from time to time 

 and see if you can produce a hyperthermia by injecting 

 /2-tetrahydronaphthylamine. Will the narcosis prevent 

 this rise in temperature in your animal? How does the 

 drug act to produce a fever temperature? Kill the animal 

 by injecting /2-tetrahydronaphthylamine. After death test 

 the urine for reducing bodies. What conclusions can you 

 draw from the experiment? Are the adrenal glands espe- 

 cially involved in any way in this experiment ? If so, how ? 

 Are there any other drugs that have this action? 



EXPERIMENT CLIX. 



Carbolic Acid (Phenol). (Frog: General Action.) 



1. Into the anterior lymph sac of a frog inject one cubic 

 centimeter of a one per cent solution of carbolic acid. Put 

 the frog in a quiet place and observe its symptoms. Do 

 you note depression or are there convulsions? What struc- 

 tures are involved in the action of the drug? 



EXPERIMENT CLX. 



Carbolic Acid, Sodium Sulphate. (Dog: Local Action, 

 Respiration, Blood-pressure, Spleen Volume, 



Antidote.) 



1. Arrange a dog for recording blood-pressure, respira- 

 tion and the volume changes of the spleen. The injecting 

 burettes contain carbolic acid (one-half per cent) and so- 

 dium sulphate (three per cent). 



With a razor shave the hair off of a spot on the dog an 

 inch or more in diameter. In the center of this spot put a 

 drop of phenol liquefactum (U.S.P. about 90 per cent- 

 make this from the crystals by adding a very little water to 

 some of the substance in a test tube and heating gently till 

 solution is effected. How does this preparation differ from 



