136 EXPERIMENTAL PHARMACOLOGY 



EXPERIMENT XII. 



Ethyl Alcohol, Brandy, Whiskey, Wine, Methyl Alcohol, 

 Amyl Alcohol. (Dog: Blood-pressure, Respiration, 



Esophagus.) 



1. Etherize a dog and arrange for blood-pressure and 

 respiratory tracings. Connect injecting burettes to both 

 femoral veins. Isolate and ligate loosely both vagi, using 

 great care not to injure them in the dissections or manip- 

 ulation or by allowing a part of either nerve to lie outside 

 the wound and to become so much dried up in the air that 

 impulses can no longer be conducted over the nerve fibers. 



Xow pull the trachea to the left side and pick up the 

 esophagus (pulling it toward the right) on a large aneu- 

 rism needle. Make a longitudinal incision about three- 

 fourths of an inch long in the side of the esophagus a little 

 way below the larynx. Xow pass through this incision into 

 the lumen of the esophagus the finger cot on the end of 

 the catheter as shown in Fig. 128. The end of the cathe- 

 ter should pass down the esophagus to a point about one 

 or two inches above the cardiac sphincter. A ligature is 

 then tied around the catheter at the esophagus incision 

 tight enough to prevent the catheter from slipping out 

 and with a hemostat the ligature ends are clamped (close 

 to the esophagus) to the neck tissues at the side of the 

 wound. The burette is now filled about half full of wa- 

 ter and the catheter is moved in and out a little to get 

 the water to run down into the finger cot. It /> important 

 for the cot to be trell filled iritli the water. Place the cork 

 in the burette and connect the tube in the cork to a medium 

 sized tambour which is adjusted for a fairly large magnifi- 

 cation. Arrange this tambour to write at the top of your 

 records; next below this should be the blood-pressure 

 (manometer) record, below this the respiration, and at 

 the bottom should be the base line marked bv a signal 



