204 



EXPERIMENTAL PHARMACOLOGY 



revive the animal. Now stimulate each vagus nerve in 

 the neck to see the effect on the heart and lungs. What 

 is the innervation of the heart and bronchioles ? If the 

 animal is still in a suitable condition, inject six cubic centi- 

 meters, of a different opium alkaloid. Do you get lung 

 records! Give some adrenaline to help revive the animal. 

 The abdomen may now be opened by a three inch median 



Fig. 195. Respiratory and blood-pressure tracings from a dog showing the progres- 

 sive actions of narcophine (Straub), narcotine and morphine. The peculiar irregularity 

 of the respiration is developed early and leads to the Cheyne-Stokes type of respiration. 

 What is the cause of Cheyne-Stokes respiration? Does the peripheral action of these 

 drugs (note the size of the doses) have anything to do with the respiratory disturbances? 

 The vagi were intact. 



longitudinal incision down near the pubic symphasis and 

 the bladder lifted up as described in Experiment XXVIII, 

 page 189. The animal will probably be dead by this time. 

 Could you thus pick up the bladder and place a cannula 

 in it in this manner in a spinal dog without letting the ani- 



