ACTION OF CANNABIS INDK'A 



205 



mal die? How might you do such an experiment and avoid 

 opening the abdomen after the brain of the animal was 

 destroyed? "What are the main differences that you note 

 between the reactions and vitality of a spinal dog as com- 

 pared with a normal animal? 



Fig. 196. Method of administering capsules, pills or tablets to dogs. The tongue 

 is pulled forward and the prepared dose is dropped far back in the mouth. The jaws are 

 held closed and the animal is gently slapped under the throat, or a little water may be 

 given. The method illustrated is frequently used in testing (standardizing) cannabis 

 indica preparations. The U.S. P. doses are: fluidextract 0.03 cubic centimeter, extract 

 0.004 gram and tincture 0.3 cubic centimeter per kilogram of body weight, for small or 

 medium-sized, smooth-haired (preferably fox terrier) dogs. Doses not larger than these 

 should produce incoordinatioii (best observed when the animal is standing still) and 

 slight ataxy in walking. The animal should be kept in a quiet room and the symp- 

 toms may not become marked (or even perceptible) for one or two hours. In three or 

 four hours the symptoms entirely disappear. The administration of 3/4 grain of "can- 

 nabinole" in oil (in globules) to a dog weighing about 4 to 6 kilos, is recommended for 

 demonstrating marked symptoms. (For the method of standardization of cannabis 

 indica, see U.S. P., ix, page 60S.) 



One may destroy the cerebrum only in an animal and 

 thus leave the medullary centers intact. This is easiest 

 done in a cat. Normal respiration may go on (no further 

 anesthetic is needed) and the blood-pressure remains high. 



