278 EXPERIMENTAL PHARMACOLOGY 



carpine on the adrenal glands? (Dale and Laidlaw: Jour- 

 nal of Physiology, 1912.) 



Kill the animal with a large dose of pilocarpine and ob- 

 tain a death record. Watch the pupils as the drug is in- 

 jected. What do you observe? What is the immediate 

 cause of death? 



If time permits open the chest and fit into it a piece of 

 apparatus like that shown in Fig. 255 (or Fig. 256, if you 

 happen to have this). Close the chest with hemostats as 

 shown in Fig. 257. Could you do this in a living animal? 

 Remove and wash all your apparatus. 



EXPERIMENT LXIX. 



Pilocarpine, Arecoline, Adrenaline, Atropine, and Barium. 

 (Dog: Bladder, Intestine, Respiration, Blood-pressure.) 



1. Etherize a dog and arrange to record blood-pressure 

 and respiration. Open the abdomen and connect a mercury 

 bulb to the bladder in the manner shown in Figs. 179 and 

 199 and arrange to record bladder contractions on the 

 tipper part of the drum (the tambour pointer will rise 

 when the bladder contracts allow space for this.) 



Observe the apparatus shown in Fig. 246 for recording 

 intestinal contractions. Arrange a burette, catheter and 

 finger cot (or rubber glove finger) as shown and make a 

 small longitudinal incision in a loop of the small intestine. 

 Slip the end of the catheter over which the finger cot is at- 

 tached about four or five inches down the lumen of the in- 

 testine from the incision. (The tip of the catheter reaches 

 entirely to the end of the finger cot and thus forces the cot 

 along.) Fill the burette half full of water and move the 

 catheter in and out a little to be sure the finger cot is filled 

 iritli water and that the air is expelled. Stitch together 

 the incision in the intestine around the catheter and close 

 abdomen with hemostats. The intestinal tambour should 



