PILOCARPHSTE, TETRAMETHYLAMMONIUM CHLORIDE 331 



Fig. 291. Tracing showing the action of pilocarpine, tetramethylammonium chloride 

 (two injections) and adrenaline on the bronchioles and blood-pressure in a spinal dog. 

 Note the peculiar combination of cardio-inhibition and vaso-constriction produced by the 

 tetramethylammonium chloride which also dilates the bronchioles, while pilocarpine, which 

 likewise causes cardio-inhibition, produces contraction of the bronchioles. Adrenaline 

 has still a different action. How do you explain these various phenomena? 



