COCAIXE AND NOVOCAINE 351 



EXPERIMENT XCIV. 

 Cocaine, Novocaine. (Local Anesthetic Action.) 



1. Cut a piece of filter paper one-half inch square and 

 saturate it with two per cent cocaine hydrochloride solu- 

 tion. Place the filter paper on the right side of the upper 

 surface of the tongue. Repeat this for the left side of the 

 tongue but use a two per cent novocaine solution in this 

 case. Do not swallow any of the solutions. Keep the 

 pieces of paper on the tongue for a few minutes (the same 

 for each drug) and then remove them. From time to time 

 test the sensitiveness of the two spots on the tongue to 

 touch, pain (pin point) and to minimal induction currents. 

 What can you say regarding the comparative local actions 

 of the cocaine and novocaine! If larger areas of the tongue 

 are covered by the solutions (to include the taste organs, 

 especially the tip and edges of the tongue) then the taste 

 sensations for sweet, salt, acid and bitter may be tested. 

 On what parts of the tongue are the taste organs to detect 

 each of these sensations located? What conclusions can 

 you draw from the experiment? Are the sensations of 

 heat and cold affected or could you determine this from 

 your experiment? Explain in detail. 



EXPERIMENT XCV. 



Cocaine. (Frog or Turtle: Heart Tracing 1 .) 



1. Pith a frog or turtle and test the action of cocaine on 

 the heart and cardiac nervous mechanism using a solution 

 containing two milligrams to one cubic centimeter of solu- 

 tion. Stimulate the vagus before and after the drug is 

 applied. Repeat this carefully in each case for the crescent 

 also. What conclusions can you draw? Have you tested 

 other drugs having a similar action? If so what ones? 



