EEGAMINE, HOEDENIXE, ATEOPINE 373 



chine! If your drug was pure and the dose suited to the 

 dog you should see the lung changes. To what do these cor- 

 respond f Was the pulmonary blood-pressure affected! 

 HOW T was this brought about? What structures were in- 

 volved and how were they affected! (See Cloetta: Archiv 

 fur experimentelle Pathologie und Pharmakologie, 1914). 

 What relation does a dilatation of the bronchioles bear to 

 the pulmonary pressure ! What relation does a contraction 

 of the bronchioles bear to the pulmonary pressure ! 



If the animal is still in a fair condition give it a dose of 

 adrenaline and change the ergamine solution for one of 

 codeine or heroine (one cubic centimeter equals five milli- 

 grams). You must work quickly for the animal may die at 

 any time. Inject five cubic centimeters of the codeine (or 

 heroine) solution (watch tlie lungs] and compare the pul- 

 monary reaction here with that under ergamine. 



Kill the dog with one of your solutions. Make a diagram 

 showing the complete innervation of the lungs. 



EXPERIMENT CV. 



Ergamine, Adrenaline (or Hordenine), Atropine. (Spinal 

 Dog, or Cat: Bronchioles.) 



(Bladder contractions may also be recorded if desired.) 



1. A number of methods have previously been described 

 for recording bronchial contractions. With positive arti- 

 ficial respiration in a spinal dog a perforated brass tube can 

 be passed through the chest, or by use of the lung shield 

 (Fig. 200) a bent glass tube can be inserted through the 

 right chest wall to record changes in the right lung only, or 

 by use of the special forms of apparatus shown in Figs. 

 255 and 256 the entire chest cavity can be used as a ple- 

 thysmograph frcm which a tube is led off to the large bowled 

 recording tambour (Figs. 14 and 372). With the negative 

 pressure method of carrying out artificial respiration by 

 means of aspirating the chest cavity after one or the other 



