380 EXPERIMENTAL PHARMACOLOGY 



Do you get a satisfactory record? Has the atropine 

 changed the influence of the drug on the bronchioles ? What 

 does this prove! How does the action of hordenine com- 

 pare with that of adrenaline? 



If the animal is still in a suitable condition (which is im- 

 probable) you may try to get another contraction of the 

 bronchioles from ergamine and then follow this with an in- 

 jection of tyramine. This drug is described as acting in 

 many respects like adrenaline. Will it dilate the bron- 

 chioles ? Stop the artificial respiration and kill the animal. 

 Disseet out both eyes and preserve them in fifty per cent 

 alcohol (or ten per cent formalin) for dissection later. 



EXPERIMENT CVI. 



Ergotoxine, Ergamine. (Cat, Guinea Pig, Dog, Rabbit: 



Uterine Strip.) 



1. From one of the animals mentioned prepare a uterine 

 strip and arrange to record its contractions as illustrated in 

 Fig. 292 (or as in Fig. 316 if you have the apparatus). The 

 drum should have a very slow speed. 



When all is ready take a normal record and see if you can 

 determine whether or not the muscle is in a strong tonus, 

 and if it is properly weighted. A good deal of experience 

 is required to get the best results from the strips. Add one 

 or two cubic centimeters of ergotoxine solution (one cubic 

 centimeter equals five milligrams) to the salt solution in 

 which the strip is suspended. Do you get a contraction? If 

 not add some more drug. Wait and see what happens. 

 What conclusions can you draw ? 



After a time change the salt solution and allow the strip 

 to record a normal contraction. Do you need to change the 

 weight? Now add two cubic centimeters of ergamine (five 

 cubic centimeters equal one milligram) to the salt solution. 

 What do you observe ? Is it necessary to add more erga- 



