440 EXPERIMENTAL PHARMACOLOGY 



EXPERIMENT CXLIV. 

 Veratrine. (Dog: Heart Tracings, Blood-pressure.) 



1. Record heart tracings from a dog showing the action 

 of veratrine. Proceed as in Experiment CXXXVII, p. 431 r 

 or Experiment CXXX, p. 418. 



(Cardiometer tracings, from the ventricles, may also lie 

 recorded in another animal.) 



EXPERIMENT CXLV. 



Apomorphine. (Dog: Vomiting Center.) 



1. Inject snbcntaneonsly into a dog (eight to ten kilos) 

 one or two cubic centimeters of apomorphine hydrochloride 

 (one cubic centimeter equals five milligrams). Leave the 

 aniir.al in a quiet place and observe its actions from time to 

 time for three or four hours. Is there any noticeable action 

 on the cerebrum or cerebellum? AVhat general symptoms 

 are produced ? AVhat conclusions can you draw from the 

 experiment ? Are the pupils affected ? Is there salivation f 

 If so how do you explain it? 



EXPERIMENT CXLYI. 



Ipecac. (Dog: Emesis.) 



1. Administer by stomach to a dog (eight to ten kilos) 

 three cubic centimeters of the fluid extract of ipecacuanha. 

 Leave the animal in a quiet place and observe its actions 

 from time to time for three or four hours. What general 

 symptoms are produced ? AVhat conclusions can you draw 

 from the experiment? AVhat are the chief differences be- 

 tween the actions of apomorphine and ipecac ? 



