ACTION OF QriNIXK 447 



EXPERIMENT CXLV1IT. 

 Quinine. (Frog: General Symptoms.) 



1. Destroy the cerebrum of a frog and inject into the 

 anterior lymph sac one cubic centimeter of quinine hydro- 

 chloride solution (one cubic centimeter equals ten milli- 

 grams). Put the frog in a quiet place, count the rate of 

 lymph heart beats and of the heart beats. Observe the ani- 

 mal carefully as the action of the drug comes on. Are 

 there any signs of central nervous stimulation? How is the 

 rate of beat of the heart and of the lymph hearts affected .' 

 Do the reflexes persist! Can you elicit a pupillary light re- 

 flex ? Save the animal to see if it survives the action of the 

 drug? What conclusions can you draw from the experi- 

 ment? 



EXPERIMENT CXLIX. 



Quinine. (Frog or Turtle: Heart Tracing.) 



1. Arrange a frog or turtle for taking heart tracings. 

 Make a normal record showing vagus stimulation. Then 

 irrigate the heart with quinine hydrochloride solution (one 

 cubic centimeter equals ten milligrams). What effect has 

 the drug on the heart muscle and on the nervous inhibitory 

 apparatus ? 



EXPERIMENT CL. 



Quinine. (Frog: Action on White Corpuscles Binz's 



Experiment.) 



1. Pith a frog and make a longitudinal incision in one 

 side of the abdomen. Carefully pull a loop of intestine 

 (leaving the mesentery intact) out through the incision. 

 Place the frog on a thin board similar to that illustrated in 

 Fig. 305, but which has a circular hole about one inch in 



