452 EXPERIMENTAL PHARMACOLOGY 



How long will it probably be before the fever returns if the 

 drug lowers the temperature to normal? AYhich of these 

 three drugs is most effective in lowering the temperature ? 



EXPERIMENT CLVI. 

 Acetylsalicylic Acid (Aspirin). (Student: Headache.) 



1. AVatch for a student or other person who has a head- 

 ache due presumably to " migraine. ' ; Consult the instruc- 

 tor and if the person affected with the headache is other- 

 wise normal give him by stomach a five grain tablet of 

 acetylsalicylic acid. Observe the action of the drug and 

 see if the headache is not decreased in about fifteen or 

 twenty minutes. The drug, in reasonable doses, is not dan- 

 gerous and often entirely stops certain types of headache. 

 Aiter half an hour another five grain tablet may be taken 

 if absolutely necessary. Do you know of any other drugs 

 that might bo used here instead of the acetylsalicylic acid? 

 If so what sized doses should be given? 



EXPERIMENT CLVII. 



Phenylsalicylate (Salol). (Student: Excretion, 



Absorption.) 



1. Take by mouth a capsule containing five grains of 

 salol. This is decomposed, on reaching the intestine, into 

 phenol and salicylic acid. Test the urine for salicylic acid 

 by adding a few drops of ferric chloride when a violet color- 

 ation appears. A positive test should be observed in one 

 to one and one-half hours. This is Ewald's test for the 

 motility of the stomach but a dose as large as one gram 

 lias been recommended for this purpose. The U.S.P. dose 

 is five grains. (For literature, see Hanzlik, P. .1. : Reports 

 of Therapeutic Research Committee, A. M. A., 1914, 3, 131.) 



