456 EXPERIMENTAL PHARMACOLOGY 



a simple solution of the crystals in water! Only about five 

 per cent of the drug can be dissolved in water.) 



Watch the action of the drug on the skin closely, noting 

 color changes, etc. After a short time wipe off the phenol 

 and see what kind of a scar is left. Quickly sponge 95 per 

 cent alcohol thoroughly over the spot and see how the color 

 and appearance of the area are affected. Of what practical 

 use may this be to you! What antidote would you apply if 

 carbolic acid had been swallowed 1 ? In what strength would 

 you use the antidote and what precautions would you take 

 to prevent its absorption! Proceed quickly with the ex- 

 periment. 



When all adjustments are made take a normal record 

 and inject five cubic centimeters of carbolic acid solution. 

 Wait for the drug to act. When the records return to nor- 

 mal again inject five cubic centimeters of the phenol solu- 

 tion. What differences do you note between the effects 

 produced by the two injections! After a time inject more 

 of the phenol and bring on a marked reaction (be sure the 

 sodium sulphate is ready and that the injecting cannula is 

 not closed off by a clot). When the animal is greatly de- 

 pressed note its condition (muscular twitchings, etc.) 

 closely and begin to inject the sulphate solution (in two 

 cubic centimeter doses frequently repeated). What effect 

 has this on the animal! How do you explain the result! 

 See if you can get the animal to return to normal. 



After a time stimulate one vagus nerve and see if the 

 heart is inhibited. Does this affect the respiration! Now 

 take a very small pledget of cotton, soak it in phenol lique- 

 factum and place it on the vagus trunk for one minute. 

 Remove the cotton and stimulate above the poisoned area. 

 Repeat the stimulation below the area. How does each 

 stimulation affect the heart and respiration? What con- 

 clusions can you draw ? 



With a stomach tube inject fifty cubic centimeters of 

 five per cent carbolic acid into the dog's stomach and wait 



