462 EXPERIMENTAL PHARMACOLOGY 



intestine and examine it histqlogically for changes in the 

 mncosa, etc. Is the stomach similarly affected? How did 

 the drug reach these organs ? Excise one kidney, preserve 

 and section it for microscopic examination. Examine the 

 liver, lungs, spleen, mesentery, etc., and see if you can de- 

 tect any abnormal changes in them. What general con- 

 clusions can you draw from the experiment? 



EXPERIMENT CLXVL 

 Antimony (Tartar Emetic). (Dog: Emesis.) 



1. Stir up forty to fifty milligrams of tartar emetic ( Anti- 

 monii et Potassii Tartras) in thirty cubic centimeters of 

 water and administer through a stomach tube to a dog. 

 Put the animal in a quiet place and observe its symptoms 

 for half an hour. What conclusions can you draw? Ex- 

 plain in detail the action of the drug. Do you know of any 

 other substance having a similar action? 



EXPERIMENT CLXVII. 



Vanadium, Sodium Hydroxide, Ammonia. (Dog: Blood- 

 pressure, Respiration, Spleen Volume, Reflex and Local 

 Actions, Intestinal or Bladder Contractions.) 



1. Arrange a dog for recording blood-pressure, respira- 

 tion, spleen (or kidney) volume and intestinal or bladder 

 contractions. Do not insert a 1 radical cannula at first but 

 carry on the anesthesia l>n dropping ether <>u a towel 

 irrapped around the dog's nose and mouth. The injecting 

 burettes contain ammonium chloride solution (two per cent) 

 and sodium orthovanadate solution (one per cent, dissolve 

 the vanadium in water and neutralize with a small amount 

 of hydrochloric acid. A deep golden yellow solution is pro- 

 duced). 



