ACTION" OF VANADIUM 



465 



a normal record (see that all writing pointers are properly 

 adjusted) and inject two cubic centimeters of vanadium 

 solution. Wait for the action of the drug to wear off and 

 then inject one-half cubic centimeter of adrenaline. How 

 do the two sets of records compare? Do you know of any 

 other metal having an action similar to vanadium 1 If nec- 

 essary (to get good records) inject another (perhaps larger) 

 dose of vanadium. On what structures does vanadium act 1 

 Can you determine this point from your experiment? 

 (Could you separate the possibility of actions occurring on 



Fig. 356. Tracing showing the action of vanadium on the volume of the excised, perfused 



spleen of a dog. 



both nerve endings and smooth muscle fibers by taking a 

 record of the bronchial contractions in another animal- 

 produced by vanadium after atropine has been given?) 

 Have you seen any indications of an action on the intestine ! 

 How do you account for this? Does the metal have a se- 

 lective action for the intestine 1 Do you know of any other 

 metal that has a similar action? 



After enough vanadium records have been obtained then 

 inject into the stomach with a stomach tube one hundred 

 cubic centimeters of ten per cent (or twenty per cent) so- 

 dium hydrate solution. Wait for the animal to die. (Be 

 sure the anesthesia is deep and regular before the NaOH 



