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PLATE IV. 

 FIGURE 1. 



Amyotrophic lateral sclerosis, Case I. 



From a section of the precentral gyrus at the upper margin of the hemisphere. 1, plexiform 

 layer. 2, small pyramidal cells. 3, medium-sized pyramids. 4, large external pyramids. 5, stellate 

 cells. 6, where giant cells should be seen. 7, layer of fusiform cells. 



The cortex is shallow, the various laminae are difficult to define, the cells in general are stunted 

 and show a distorted arrangement, and, most important of all, giant cells are remarkable for their 

 absence. Some distended blood-vessels are seen. 



FIGURE -. 



To be compared with Figure 1. From a section of a normal brain, cut of the same thickness, 

 stained by a like process and taken from an identical position. 



Magnifications x - S T - and x i|i. 



