MICROBIAL DISEASES OF MAN AND DOMESTIC ANIMALS 783 



from the farcy buds is clear and viscid. Farcy cases respond to the 

 mallein test; lymphangitis cases do not. 



It seems to have been well established that Saccharomyces farci- 

 minosus is the direct cause of mycotic lymphangitis at least of one 

 form of it. 



The Saccharomyces grows in the animal tissues and by its presence 

 and products acts as a direct exciting cause of the disease. Entrance 

 is effected through wounds which may be very superficial and very 

 trivial, most frequently perhaps on the legs, shoulders, and neck. 

 The incubation period varies from a few weeks to several months. 



This Saccharomyces is distributed through lymph vessels, chiefly 

 superficial ones, the nodules appearing first near the point of 

 inoculation. 



The tissue changes produced are infection, inflammation, and 

 suppuration of the lymph vessels and glands. At first the lymph 

 vessels enlarge and harden; then nodules develop under the skin along 

 the course of the vessels. These nodules suppurate and the small 

 abscess cavity fills up with bright red granulation tissue. An entire 

 limb may enlarge very greatly by reason of excessive connective- 

 tissue formation, and the greatly thickened skin. 



Saccharomyces farciminosus is a yeast-like fungus, ovoid in shape and 3/1 to 5^ 

 long by 2. 5/j to 3.5/4 broad. This fungus grows slowly under artificial conditions on 

 agar and bouillon after inoculation with pus from an abscess. It reproduces by 

 budding and does not stain well by common laboratory stains. Claudius' method 

 of staining gives good results. 



Cases should be isolated and stables disinfected by the free use of 

 very strong disinfectants as this Saccharomyces is not easily killed by 

 ordinary disinfecting solutions. 



Another mycotic organism has more recently been reported* 

 in the United States as causing a lymphangitis very similar clinically 

 to the lymphangitis caused by Saccharomyces farciminosus. Cases 

 supposed to have been plain cases of the Saccharomyces form showed 

 on laboratory examination a Sporothrix acting as the direct cause. 

 These workers* reproduced cases by inoculation and recovered an 

 organism differing very materially from Saccharomyces farciminosus. 



* Sporothrix and Epizootic Lymphangitis, Paige, Frothingham, and Paige. Journal 

 Medical Research, Vol. XXIII, No. i. This has been previously reported by Shenck, Hek- 

 toen, and others for the human. 



