256 



COLLECTED STUDIES IN IMMUNITY. 



amount of complement can readily result owing to the deflection 

 phenomenon whose significance was first pointed out by M. Neisser 

 and Wechsberg. 1 



TABLE IV. 



A. 1 cc. 5% Ox BLOOD + AMBOCEPTOR OP GOATS TREATED WITH Ox BLOOD + 

 GUINEA-PIG SERUM AS COMPLEMENT. 



B. THE SAME + RABBIT SERUM AS COMPLEMENT. 

 C. THE SAME + SHEEP SERUM AS COMPLEMENT. 



The problem is more difficult in those cases in which the red blood- 

 cells contain a plurality of receptor units and therefore bind a mul- 

 tiple of amboceptor units. In these cases the result of the experi- 

 ments will depend mainly on the following factors. 



We know that as a rule the affinity of the amboceptor's comple- 

 mentophile group is increased when the cytophilc group is anchored 

 by the receptors. If this relative increase of affinity is very large, 

 the added complement will combine exclusively with the anchored 

 amboceptor, and in certain doses will effect solution. In this case 



M. Neisser and Wechsberg, see page 120. 



