472 



COLLECTED STUDIES IN IMMUNITY. 



TABLE I. 

 1 cc. 5% Ox BLOOD + 0.2 cc. 0.1% LECITHIN. 



' ID comparison to the original aqueous solution of venom. 



The assumption that the cobra amboceptor is extracted by chloro- 

 form alone is refuted by control tests. 



The neurotoxic action of the native poison is entirely absent in 

 the cobra lecithid. Relatively large quantities of the lecithid in 

 aqueous solution can be injected subcutaneously into animals with- 

 out producing constitutional symptoms. For example, an amount 

 of lecithid which suffices to destroy 200 cc. mouse blood can be 

 injected into mice weighing 15 grms. without causing any further 

 symptoms than infiltration at the site of injection. In like manner 

 rabbits can be injected subcutaneously with 10 cc. of a 1% solution 

 of the lecithid without causing any constitutional symptoms. In this 

 case, however, the local reaction is extensive, the infiltrated area 

 often including a considerable portion of the abdominal surface. 



