TENSION' PHENOMENA OF I.IVIM, ELEMENTS. 



not prevent but even produce a current of injury, in this \vay 

 explaining data which might otherwise seem to contradict the 

 first statement. Galeotti and Cristina 1 observed that ether, 

 ethyl-chlorid, and chloroform produce a current of injury on 

 's nm-cle. 



\\'e may conclude, then, that anaesthetic-, in the concentration 

 prodiK ing narcosis, so change the pl,t-ma membrane as to 

 pri-Miu -.tits from making it permeable to anions. This i- 

 pn.bably a No true of nerve, since Hober found th.it cthyl- 

 intili UK in low concentration prevented the- -cii-iti/ing of 

 in i \ e \\ ith I\_M)<. 



Hi'lit-r In- attempted to connect these facts with tin 1 lipoid 

 >olul)iliiy of narcotics. Moore and Roaf 2 h.nl ob-er\vd that 

 // i/utinlilics of such narcotics as chloroform, alcohol. ether. 

 "i brn/ul. precipitated lipoids extracted from organ- and -u - 

 prmlrd in \\ater. Hut Hober and Gordon"* found that colloidal 

 solnii.ui- i.i' Irdthin were not precipitated, but were made tran 

 j '.in-lit b\ i-ilu-r or chloroform in hi^h concentration. SimilarK, 

 ( n.ld-( hmidt and 1'ribram 4 observed that lecithin .-n-])cnilrd in 

 Na< I -i.liitioii, which is dissolved by chloral hydrate, methane. 

 or ' '" linr. in high concentration, is precipitated by tin m in 1"\\ 

 Concentration, < >u the other hand, Koch and Mcl...ii, 

 that hli.ral. hypnon, acetone, or pure ether, do nut change the 

 H/e i't ti'llnidal particle.s of lecithin (i. e., make them ta-ii-r or 

 more diiticult to salt out). Calugareanu 6 explain- the mech.m- 

 JMU of tlu- precipitation ol lipoids by anaesthetic- by tin incn 

 in >i/.- of the particles due to absorption of the an.e-thetic. 



Tim- there seems to be a parallel difference bet \\een tin- action 

 of low and high concentrations of anaesthetic-, <> nni-clc ami 

 nerve, and the action of the same on lipoid -u-pi-n-ion-. but this 

 dm-- not hold true for all cases. Moore and l\oa! 7 conclude that 

 ana -thetii - are bound, not only by lipoids, but al-o by pn.teids, 



1 , :ol.. IQIO, X.. I. 



>ndon. 1904. LXXIII.. 38 . LXXVII., 86. 

 //. I^-ilrage, 1904, \'.. 432. 



h. H. Ther., 1909. \'I.. i. 

 Jour. 1'lxirm. and Exp. Ther., 1910, II.. 9 

 . 1910, XXIX.. 96. 



