kI-:.\I)KRIN<; KK-I-TANI -T. \KI1-H EGGS V'KMAL ; v - 



eytoly-i- within 12 to 15 hours or less. T"\\,inl the end of 

 June r;^> become fewer and more variable in quality, many 

 fail to maturate and the mature e;^-on fertilization tend to dea\ e 

 irregularly and largely die before rearhini; the Mastula Stage; a 

 vop. inion of evji:- -how the abiiormalil : ribed al><>\e; 



iin n-a-ed re-i-ian< e to fertili/atii >n ami t> r\ tolvnr alteration 

 iallv character!-: :< and indicates that the pla-ma mem- 

 brane li.i- In-come aluiormalK- reM-tant l> change- in permeal 'ilit\\ 

 I have dc-criliril tin- jieculiariiii - of thes< eggs in -uMirient 

 detail above, and ha\e aln-ady brietK" <lixil ed the phy-in- 



cal n.itnn- of the al'iiormalitii -. I'he failure to re-pond 

 normally in |Crt ili/alion ln-r<ime- intelli^il >Ie on the h\pot!; 

 that the essential Or critical event in the initiation of tvll-di\ i-in 

 icmpor.ir\ and r \ti~iblr increase in the ioni,- ju-rnu-al -ilitx 

 Ol tin- pla-ma nieml ifaiu-. ^u. h a .1 ; n\ol\e- a il. 



in the rlt-i tiital pdlari/atimi of the nu-mbrane. and it appeal-- 

 pr-'baHr as ill the allalo^ni- ( a-r of mil-(le and ner\ i- that 

 tin- c hair^i- <! polai i/at imi. and not ihr men- in> 

 mcabilitN a- -mil. i- tlu- rritiral i\i-nt \\hich initiate- the rh\th- 

 mii-.il - : |'h\-iial and ( hemical p- : \\hich rKa\ 



i- tin- normal c\|.|, In md-r that il:< -na\ n -pond 



he ' "in. ui and entra: Mialo/oi'm in a normal 



manner, it- |>la-ma membrane mn-t ha\c a '(ilain delimit- 

 ph\ lemii al i on-iiuitii.n -uch that the -nb-tan ins- 



mitttd b\ thi rmatOZOdn 1 max t lit t an im rea-i- of perme- 



ability uhiih in rate and derive a| >pro\imaie- a <riain norm. 

 Thi- imp!' istance \< > ehan^e oi jn-rn 



bilit\ : if thi- resistance i- abnormal!'. . tin- iv-pon-e tail- 



OCCUr or i- imperlet t ; it abnonnalU 1.\\ . the -pi-rmaio/' -on 

 effects tOO ^reat and tOO la-iin^ an increase in permeability 



1 M\- tlif lil- 



'.1. ;iri-i;.. 

 |K>l.iii/.itii>ii MI tin- limitm.i: n : i!i-.ii'; 



itimi^ in : rlnilui: :i "I tin- liiniiiiiK 



IIU-H. : .1 lllltllcr UN. 



. 1 tn,-r. J 



] 7' i- 



.iin ly-in-lik. 

 Iling these " membranol) miul 



Il.ttllK- "I t: .;i. 



