44 LEO LOEB. 



3. It is shown that, notwithstanding the presence of a hyper- 

 trophic interstitial gland, there was an absence of male secondary 

 sexual characters and that the mammary gland had a female 

 character. A provisional interpretation of these facts is given 

 on the basis of our present knowledge of sex determination. 



LITERATURE. 



1. P. Bourn et P. Ance!. 



'03 Archiv. de Zool. exper., Serie IV., 1903, I., 437, and 1905, III., 390. 



2. Julius Tandler u. Siegfried Grosz. 



'13 Die Biologischen Grundlagen der Sekundaren Geschlechtscharaktere- 

 Berlin, 1913. 



3. R. H. Whitehead. 



'08 Anat. Record, 1908, II., 177. 

 4 I. Bergonie et L. Tribondeau. 



'05 C. r. Soc. Bio!., 1905, LVIII., 155. 



5. G. Herxheimer u. K. F. Hoffman. 



'08 D. Med. Wochensch., 1908, XXXIV., 155. 



6. Leo Loeb. 



'07 Zentralblatt f. allg. Pathol., 1907, XVIII., No. 14. 



'08 Journ. Amer. Med. Assoc., 1908, 1897. 



'09 Archiv. f. Entwickelungs Mech., 1909, XXVII., 89; 1909, XXVII., 463. 



7. E. Steinach. 



'12 Pflueger's Arch., 1912, CX., LIV., 71. 



8. E. Steinach. 



'13 Zentralblatt f. Physiol., 1913, XXVII., 717. 



9. Leo Loeb and Cora Hesselberg. 



'i7journ. Exp. Med., 1917, XXV., 285 and 305. 

 10. T. H. Morgan. 



'13 Heredity and Sex. New York, 1913. 

 n. L. Doncaster. 



'14 The Determination of Sex. Cambridge, 1914. 



12. Jacques Loeb. 



'16 The Organism as a Whole. New York, 1916. 



13. R. Goldschmidt. 



'16 Amer. Naturalist, 1916, L., 705. 



14. F. R. Lillie. 



'17 Proc. Nat. Acad. Sciences, 1917, III., 464. 



ADDITIONAL NOTE 



The foregoing paper was written without the knowledge of 

 two quite recent, very important publications by F. R. Lillie and 

 C. L. Chapin, which may have some bearing on our observations, 

 and which it will therefore be necessary to briefly discuss from 



1 F. R. Lillie, Journal Exper. Zoology, 1917, XXIII. , 371. C. L. Chapin, ibid. 

 453. I am much indebted to Prof. Lillie for calling my attention to these papers, 



