556 ANNUAL RECORD OF SCIENCE AND INDUSTRY. 



any drawback being attached to its judicious use. 3 A, De- 

 cember 9, 1871, 452. 



CAMPHOR AND BROMINE. 



Among the new preparations in the materia medica, men- 

 tion is made of the use of a combination of camphor and bro- 

 mine, which is claimed as an excellent sedative of the nervous 

 system. It has been used, as stated, with good effect in such 

 cases of excitement as threaten to pass into a true delirium 

 tremens. The medicine is given in the form of pills : TO 

 grains being made into 30 pills, one of which is to be taken 

 every hour until 20 are taken, after this the quantity being 

 somewhat decreased. 



COMBINATION OF CHLOROFORM AND MORPHINE IN 



ANAESTHESIA. 



Some time ago Professor Claude Bernard ascertained that 

 if a hypodermic injection of morjmine be introduced into the 

 system, a very complete anaesthesia will be produced by a 

 much less quantity of chloroform than would otherwise be 

 required. Messrs. Labbe and Guion have also been practi- 

 cally testing this same question. The experiment has been 

 tried of making an injection of morphine while a patient to 

 be operated on was under the influence of chloroform ; this 

 resulting in profound sleep, prolonged for several hours after 

 the operation. The gentlemen referred to prefer to intro- 

 duce the injection before the use of the chloroform, not so 

 much for the purpose of preventing pain as for facilitating 

 the production of anaesthesia, and rendering it less dangerous 

 by reason of the smaller quantity of chloroform employed. 

 In one case two centigrammes of morphia w T ere injected, and 

 after this twenty-eight grammes of chloroform were inhaled. 

 In seven minutes anaesthesia was complete, and was pro- 

 longed for many minutes after the end of the operation, 

 which lasted seventeen minutes. In another case the chloro- 

 form was given twenty minutes after the injection, and com- 

 plete anaesthesia was produced in six minutes, extending 

 through the operation, which lasted an hour and forty-five 

 minutes. The total expenditure of chloroform was only for- 

 ty-eight grammes. 



It is not at all improbable that further experiments will 



