PART II. 



STATISTICS OF EXPERIMENTS ON THE METABOLISM OF DIABETICS. 



These experiments were all made with patients from the private practice 

 of one of us. Frequently the patients were placed in the New England 

 Deaconess Hospital, within a short distance of the laboratory, and the diet 

 strictly controlled. Others lived in or near Boston and made periodic visits 

 to the laboratory for experimental purposes. 



CLASSIFICATION OF CASES. 



The cases were divided into groups with particular reference to severe, 

 moderately severe, and light diabetes. The basis for this classification has 

 been essentially that outlined in our previous publication, namely, under severe 

 diabetes were classed all those who failed to become sugar-free, even though all 

 carbohydrates except the green vegetables were excluded from the diet, or 

 those who became temporarily sugar-free upon vegetable days which were fol- 

 lowed by a low quantity of protein in the diet. The cases in this group invari- 



Table 2. Description of cases used in the studies on diabetes. 



No. of 

 case. 



Desig- 

 nation 

 of case. 



Sex. 



Age at 

 onset. 



Onset. 



Present condition. 



Duration. 



220 

 2S3 

 246 

 319 

 373 

 201 



235 



310 

 295 

 289 

 210 

 228 

 177 

 281 

 194 

 441 

 371 

 344 



336 

 381 

 332 

 320 

 333 

 317 



A 

 B 

 C 

 D 

 E 

 F 



G 



H 



I 



J 



K 



L 



M 



N 



O 



P 



Q 



R 



S 

 T 

 U 

 V 



w 



X 



M. 

 F. 

 M. 

 M. 

 M. 

 M. 



M. 



F. 

 M. 

 M. 

 M. 

 M. 

 M. 

 M. 

 F. 

 M. 

 M. 

 M. 



M. 

 M. 

 F. 

 M. 

 F. 

 M. 



39 

 39 

 28 

 31 

 17 

 22 



31 



17 

 13 

 18 

 44 

 21 

 47 

 12 

 13 

 16 

 13 

 40 



46 

 41 

 35 

 35 

 16 

 32 



Gradual, 1900 



Gradual, Dec. 1908. 

 Acute, Sept. 1908.. . 



Mar. 1909 



Sept. 1907. 



Died, Aug. 24, 1910 



Died, coma, Apr. 13, 1910. 

 Died, coma, Dec. 8, 1909. 

 Died, coma, Jan. 13, 1910. 

 Died, coma, Oct. 13, 1909. 



yrs. mos. 

 10 .. 



Jan. 1908 Died, pneumonia (?), Feb. 1910 



{^lSS&& Jaa :. 190 . 1 :. } D -d. coma, May 4, 1910... 



1889 



1900 



Feb. 1908 



Nov. 1907 



July 1908 



1900 



Julvl909 



Feb. 1908 



Dec. 1910 



Sept. 1909 



Nov. 1903 



Died, coma, May 3, 1910 



Died, May 1912 



Died, Sept. 17, 1912 



Died, coma, Nov. 4, 1910 



Active work, Nov. 11, 1912 



Active work, Nov. 11, 1912 



Died, coma, Feb. 16, 1911 



Died, coma, Dec. 10, 1910 



Died, coma, Nov. 5, 1911 



Died, coma, Mar. 14, 1911 



Died, pulmonary tuberculosis, 



Mar. 14, 1912 



Died, coma, Oct. 19, 1910 



Died, coma, Mar. 5, 1911 . 



1899 



Sept. 1908 



Apr. 1909 ] Died, coma, Aug. 11, 1911 



July 1909 Died, Feb. 6, 1911 



Nov. 1908 Comfortable, Nov. 11, 1912 



July 1903 Comfortable, May 8, 1912. . 



5 



21 



12 



4 



3 



4 



12 



1 



2 



11 



2 

 2 

 1 

 4 

 3 



4 

 3 



10 

 1 



1 

 4 



7 

 10 

 11 



6 



6 



4 

 7 



10 



ably showed a minus carbohydrate balance when the diet was considerably 

 restricted. The second criterion for determining the severity of the case was 

 the presence of an acidosis. Under moderately severe diabetes were classed 

 those who became sugar-free and showed a positive carbohydrate balance, or 

 with whom the acidosis was either very slight or absent. Only one case of 

 light diabetes was included in the study. This was a fat man, Case M, who 



15 



