STATISTICS OF EXPERIMENTS. 



37 



Family history. No history of diabetes in the family. Father died of 

 pneumonia; mother and brother well. 



Past history. Scarlet fever, dysentery at 3 years of age, measles, mumps, 

 whooping-cough, chicken-pox, enuresis nocturna which ceased at the age of 4. 

 Had always a voracious appetite, sometimes eating six potatoes at a meal; ate 

 much candy. 



General history of the case. During the year preceding the onset of the dis- 

 ease the patient developed rapidly both in height and weight. In February 

 1908, she showed weariness. Early in March, polydipsia, polyuria, and poly- 

 phagia were present, and sugar was demonstrated in the urine. One year pre- 

 vious the urine had been examined and was said to be normal. 



During the whole period of illness the patient remained in good condition 

 and attended school with comfort. The diet was rigidly adhered to and not 

 relaxed except when the diagnosis was at one time doubted by the local physi- 

 cian. Catamenia was established for the first time in March 1909. No 

 essential change in the physical examination took place. The patient died in 

 coma on December 10, 1910. 



Table 33. Comparison of metabolism experiments in bed calorimeter with Case N. 



EXPERIMENTS WITHOUT FOOD. 



1 About 1 hr. 15 min. before experiment began, subject drank a small cup of black coffee. 

 2 About 1 hr. 30 min. before the experiment began, subject ate 300 gms. of cooked oatmeal. 



Physical examination. A healthy appearing girl. Greatest weight, Janu- 

 ary 1908, 60.8 kilos, without clothing; weight, April 20, 1908,49.2 kilos, without 

 clothing. Height, 173 cm. No acetone odor. Pupils equal and reacted to 

 light; tongue and teeth normal. Few cervical and axillary glands. Apex of 

 heart within nipple line; no murmurs. Nothing abnormal felt in abdomen. 

 Knee-jerks normal. The greatest quantity of urine was approximately 5,000 

 c.c, just previous to April 18, 1908. 



Urine data. The course of the disease is given in table 34. Although the 

 urine showed 4.8 per cent of sugar on April 18, 1908, it will be seen that under 

 the restriction of the carbohydrates to approximately 10 grams the urine 

 became sugar-free. The tolerance for carbohydrates gradually increased, and 

 reached approximately 90 grams of carbohydrates in February 1909, where it 

 remained until after October 28, 1909. The weight rose from 49.2 kilos., April 

 20, 1908, to 55.8 kilos., July 28, 1909. The health was so good that the local 

 physician would not believe that the patient had diabetes, and allowed a free 

 diet on Thanksgiving Day, 1909. Sugar returned early in December 1909, but 

 disappeared at once when the diet was again restricted. A tolerance of 55 



