STATISTICS OF EXPERIMENTS. 



77 



Family history. No history of diabetes in the family. Father had rheu- 

 matism. Mother, three brothers, and five sisters are well. Two brothers 

 died of cholera infantum; one sister of spinal meningitis. 



Past history. Measles, mumps, chicken-pox. March 1907, operation for 

 appendicitis, with good recovery. 



General history of the case. In November 1908 the patient was markedly 

 tired, and in January 1909 pruritus appeared and sugar was found in the urine. 

 In February 1909 she suffered from periods of weakness, but was not uncon- 

 scious. Micturition was painful. Polyuria and polydipsia were present, but 

 not polyphagia. During the summer of 1909 she suffered pain in the left iliac 

 fossa, which was constant in character and accompanied by abdominal tender- 

 ness, but no fever. The pain was worse before catamenia, which was reported 

 as normal in April 1910. Although suffering from indigestion, she vomited but 

 once. She was nervous, and complained of dizziness, dyspnea, and palpitation. 

 August 1909 an obstruction was found in the ureter by Dr. Chute. April 16, 

 1912, the patient was in comfortable health. 



1 No sodium bicarbonate given except 8 gms. on May 23-24. 



2 Per cent. 



NH3 N 



8 Ammonia, 1.2 gm8.; _ , , __ =11.8 per cent. 4 Catamenia. 6 Per cent by fermentation. 



lotal N 



Physical examination. Greatest weight without clothing, 63.5 kilos.; 

 August 1909, 51.7 kilos.; April 30, 1910, 61.1 kilos. Height, 161 cm. Red 

 cheeks. Pupils equal and reacted to light. Knee-jerks normal. No cervical, 

 axillary, or inguinal glands felt. Pulse-rate, 112 to 128. Blood-pressure, 130. 

 Heart 13 cm. to the left of the median line. No murmurs. Lungs normal. 

 Liver extended 2 fingers' breadth below the costal margin. Spleen and kidney 

 not felt. No abdominal tenderness. Scar in appendix area. 



Urine data. The greatest quantity of urine recorded was in July 1909 

 i. e., 4500 c.c. The urinary record during observation is given in table 96. 

 Throughout this period the reaction was acid, with an occasional slight trace 

 of albumen. Diacetic acid was not present. The sugar in the urine decreased 

 rapidly with moderate restriction of the diet, and disappeared within three 

 weeks. A subsequent report, however, showed a return of sugar a few months 

 later. Sodium bicarbonate was given only once 8 grams on May 23-24, 1910. 



