86 



METABOLISM IN SEVERE DIABETES. 



The average for all of the diabetic subjects shows a minimum pulse-rate of 

 65 beats per minute, and a maximum of 81 beats. The average maximum and 

 minimum pulse-rates for the normal subjects are 54 and 74 respectively, both 

 materially lower than the averages found for the diabetic subjects. In prepar- 

 ing these tables, care was taken not to include any records obviously affected 

 by excitement or other untoward incident in connection with the experiment, 

 three records approximately constant usually being taken as indicating the 

 maximum or minimum. The values given can therefore be considered as repre- 

 senting the average normal variations in pulse-rate to be expected for normal 



individuals under the conditions of experimenting as employed in this labora- 

 tory, and for patients with severe diabetes. It will be seen, therefore, that both 

 the minimum and maximum pulse-rates of normal individuals are markedly 

 lower than those of diabetics. 



It must furthermore be remembered that in practically every instance the 

 normal individual led a much more active life, had much greater muscular tone, 

 and was more restless than were the diabetics. This makes the difference in 

 pulse-rate all the more striking, since one would ordinarily expect a somewhat 

 higher value with the more active and restless normal subjects than with the 



Table 109. Pulse-rate of normal subjects. 



Subject. 



C. H. H.. 

 M. A. M.. 

 Miss B . . . 

 Dr. S.... 

 H. F. T.. 

 E. P. C. 

 K. H. A.. 



J. R 



O. F. M.. 



weak, sick diabetics, disinclined to any extraneous muscular motion. An 

 examination of tables 108 and 109 shows no regularity in either the minimum 

 or maximum pulse-rates when individual diabetics are compared with normal 

 individuals, since some of the diabetic subjects show a minimum pulse-rate con- 

 siderably lower than the average minimum pulse-rate of the normal subjects; 

 and similarly, the normal individuals in some instances show a pulse-rate con- 

 siderably higher than the average maximum pulse-rates of the diabetics. On 

 the whole, however, a distinct tendency toward an increased pulse-rate in 

 diabetics is here clearly shown. This increase is fully in conformity with the 



