DISCUSSION OF RESULTS AND GENERAL CONCLUSIONS. 



107 



Table 121. Average carbon dioxide eliminated per kilogram of body-iveight per minute hj 

 diabetics in experiments without food, 1908-1911. 



Subject. 



Severe diabetes 



Case A 



B 



C 



D 



E 



F 



G 



H 



I 



J 



K (1910)... 

 L (1910)... 



N 



O 



P 



Q 



R 



S 



T 



Chair 

 calorim- 

 eter. 



28 



i(j 



29 



41 



32 



72 



Bed calo- 

 rimeter. 



c.c. 

 3.22 

 3.23 

 2.95 



3 22 

 3.10 

 4.33 



4.11 



3.36 

 3.51 



3^29 



Respiration 

 apparatus. 



c.c. 

 2.89 

 3.05 

 2.90 

 3.11 



3.04 



3'48 

 3 31 

 3.08 



3 '.00 

 3.75 



2.64 



Subject. 



Severe diabetes Con. 



CaseU 



V 



Av. severe cases. . 



Av. all expts.with 

 bed calorimeter 

 and respiration 

 apparatus , 



Moderately severe 

 diabetes. 



CaseK (1909) 



L (1909) 



W 



X 



Av. moderately 

 severe cases . . 



Light diabetes. 



CaseM 



OXYGEN CONSUMPTION IN DIABETES. 



The quantitative measurement of the oxygen consumption of diabetics has 

 been attempted only by means of the Zuntz-Geppert apparatus/ by Weintraud 

 and Laves with the Hoppe-Seyler apparatus, 2 and by us 3 in our earlier investi- 

 gations. 4 The difficulties incidental to the accurate determinations of the oxy- 

 gen consumption have precluded a more general measurement. On the other 

 hand, exact determinations of the oxygen used by the subject have greater 

 significance as an index of the calorific output of the body than have the deter- 

 minations of the carbon-dioxide excretion, especially with normal individuals. 

 With diabetics, as we have shown earlier, particularly with severe cases, the 

 carbon-dioxide determinations, if accurately made, may be considered equally 

 as good an index of the heat production as is the oxygen. Nevertheless it 

 remains a fact that quantitative determinations of oxygen have a special sig- 

 nificance and are of unusual importance and interest. Since especial emphasis 

 is laid in this report upon the severity of diabetes, in connection with the dis- 

 cussion of the metabolism during diabetes mellitus we have deemed it advis- 

 able in table 122 to present again the oxygen determinations obtained in our 

 earlier investigations, accentuating here the oxygen determinations found with 

 the severe cases rather than the total average. 



'Leo (1891), Stiive (1894), Nehring and Schmoll (1897), Magnus Levy (1905), Mohr 

 (1907). 



'Weintraud and Laves, Zeitschr. f. physiol. Chem., 1S94, 19, p. 603. 



' Benedict and Joslin, Publication No. 136, Carnegie Institution of Washington, 1910. 



4 Two articles have recently appeared giving reports of studies made by Roily and by 

 Leimdorfer of the oxygen consumption of diabetics. Unfortunately these did not come to 

 our attention until after this report had been sent to the printer, and therefore scant com- 

 ment only is possible in the proof. Roily in Leipsic used a modified Benedict respiration 

 apparatus. See Roily, Deutsch. Archiv f. klin Med., 1912, 105, p. 494. Leimdorfer in von 

 Noorden's laboratory used the Zuntz-Geppert method. See Leimdorfer, Biochem. Ztschr., 

 1912, 40, p. 326. 



