132 



METABOLISM IN SEVERE DIABETES. 



On the experimental day the subject came to the laboratory fasting, and 

 the experiment began at 7 h 55 m a. m., continuing for two periods of approxi- 

 mately 15 minutes each and ending at 8 h 39 m a. m. During the experiment 

 the pulse-rate ranged from 72 to 75. The measurements of the metabolism 

 are given in table 138. 



RESULTS OF EXPERIMENTS WITH H. H. A. 



The measurements of the total metabolism of the subject for the whole 

 series of experiments are given in table 138. Previous to the first experiment 

 the subject had been on a normal diet, but fasted for some 12 hours before com- 

 ing to the laboratory. Under these conditions he absorbed about 225 c.c. of 

 oxygen per minute and had an average pulse-rate of approximately 78. On 

 the morning following the carbohydrate-free diet, the oxygen absorption was 

 increased to approximately 255 c.c. per minute, and the pulse-rate to 83. On 

 the next four days of the carbohydrate-free diet, the metabolism remained 

 high, although there was a tendency for it to approximate more nearly the 

 normal level as the experiment progressed. Singularly enough, notwithstand- 

 ing the high metabolism, the pulse-rate on the first two days was considerably 

 below that on the normal day. Unfortunately simultaneous observations 

 with regard to the blood-pressure were not obtained. 



'Sugar and albumen tested for each day and uniformly absent. 



Subject ate 582.8 gms. cooked oatmeal and 83.6 gms. butter at 12.12 p.m.; also 350.7 gms. cooked oatmeal and 65.1 

 gms. butter at 4.35 p.m. See statistics of experiment No. 7. 



'Subject took 100 gms. cane sugar in 400 c.c. of water with juice of lemon at 9.12 a.m. For diet rest of day see sta- 

 tistics of experiments Nos. 8 and 9. 



Urine analyses. The urine was collected in 24-hour periods from Decem- 

 ber 25 to January 4, although on certain days the determinations were made in 

 periods corresponding to the experimental periods. The results of the urine 

 analyses are given in table 139. Only one determination of the /3-oxybutyric 

 acid was made, i. e., on the fifth day of the carbohydrate-free diet, and 4.8 

 grams of /3-oxybutyric acid were found. There was no diacetic-acid reaction, 

 but the percentage of ammonia-nitrogen to total nitrogen was somewhat higher 

 than normal, if not excessively high. On the oatmeal and cane-sugar days 

 following the carbohydrate-free diet, the percentage of ammonia-nitrogen in 



