2 CALORIMETERS FOR STUDYING RESPIRATORY EXCHANGE, ETC. 



carried on simultaneously with academic duties, it appeared absolutely 

 necessary to adjust the research so that the uninterrupted time of the ex- 

 perimenters could be given to work of this kind. Since these experiments 

 frequently continued from one to ten days, their satisfactory conduct was 

 not compatible with strenuous academic duties. 



As data regarding animal physiology began to be accumulated, it was 

 soon evident that there were great possibilities in studying abnormal meta- 

 bolism, and hence the limited amount of pathological material available in 

 Middletown necessitated the construction of the laboratory in some large 

 center. 



A very careful consideration was given to possible sites in a number of 

 cities, with the result that the laboratory was constructed on a plot of ground 

 in Boston in the vicinity of large hospitals and medical schools. Advantage 

 was taken, also, of the opportunity to secure connections with a central 

 power-plant for obtaining heat, light, electricity, and refrigeration, thus 

 doing away with the necessity for private installation of boilers and electrical 

 and refrigerating machinery. The library advantages in a large city were 

 also of importance and within a few minutes' walk of the present location 

 are found most of the large libraries of Boston, particularly the medical 

 libraries and the libraries of the medical schools. 



The building, a general description of which appeared in the Year Book 

 of the Carnegie Institution of Washington for 1908, is of plain brick con- 

 struction, trimmed with Bedford limestone. It consists of three stories and 

 basement and practically all the space can be used for scientific work. 

 Details of construction may be had by reference to the original description 

 of the building. It is necessary here only to state that the special feature 

 of the new building with which this report is concerned is the calorimeter 

 laboratory, which occupies nearly half of the first floor on the northern end 

 of the building. 



