50 



Influence of Inanition on Metabolism. 



body and the calorimeter) = 9-10.88 calories. Similarly, at 10 a. m. the body 

 weight was 67.597 kilos, and the difference between body temperature and 

 calorimeter temperature was 17. The formula would then be 67.597 X 0.83 

 X 17.0 = 953.80. The difference between the amounts of heat in the body 

 reduced to 20 at 7 a. m. and 10 a. m. is 953.80 940.88 = 12.92 calories. 

 There were, therefore, 12.92 calories of heat stored in the body more than 

 were present at 7 a. m., and consequent^, since this quantity of stored heat 

 was derived from the heat produced during this period, it should be added to 

 the heat eliminated to give the heat production. The results for all the 

 different periods are recorded in column e. 



Relation of heat production to lieat elimination. The total heat production 

 is the heat eliminated corrected for changes in the amount of heat residual 

 in the body. The corrections for the heat elimination have previously been 



Table 18. Amounts of body protein, fat, and glycogen katabolized and energy of 



each 1 Metabolism experiment No. 59. 



1 Factors for heat of combustion per gram of protein, 6.65 calories; fat, 9.54 calories; glycogen, 

 4.19 calories. 



considered and are tabulated in columns c to g of table 14. The corrections 

 for the changes in the amounts of heat residual in the body as found in table 16 

 are applied to the corrected heat elimination and thus the total heat production 

 is obtained. These results are shown in table 17. 



Energy of body material lost. The quantities of protein, fat, and carbo- 

 hydrates katabolized in the body have been computed from the chemical analyses 

 and the formulae given on page 38. The energy of these compounds may be 

 computed from the weights katabolized and the heats of combustion of body 

 protein, fat, and carbohydrates. The heat of combustion of fat-free muscular 

 tissue from which the nitrogenous extractives have not been removed is not far 

 from 5.65 calories per gram. A large number of determinations of the heat of 

 combustion of human fat made in this laboratory " averaged 9.54 calories per 

 gram. The heat of combustion of glycogen has frequently been determined 

 as 4.19 calories per gram. The computation, therefore, of the energy resulting 

 from the katabolism of any one of these three different compounds in the 



"Benedict & Osterberg, Amer. Journ. Physiol. (1900), 4, pp. 69-76. 



