142 



Influence of Inanition on Metabolism. 



of Professor Mendel who was assisted in his analyses by Mr. 0. E. Closson. 

 The urine voided during the last 3 days of the experiment was of such a 

 character that only an approximate estimate of the amount of uric acid based 

 upon the maximum solubility of ammonium urate could be made. 



The chlorine determinations were made according to the Volhard method. 

 In line q of the table they are expressed as the element chlorine, but to 

 facilitate a comparison with, the output in other experiments the chlorine is 

 calculated as sodium chloride and it is so recorded in line r. 



Table 95. Weight, composition, and heat of combustion of urine Metabolism 



experiment No. 73. 



Jan. 



28-29. 



Jan. 

 29-30. 



Jan. 

 30-31. 



Jan. 31- 

 Feb. 1. 



Feb. 

 1-2. 



Total for 

 6 days. 



(a) Weight grams. 



(6) Water do... 



(c) Solids, a b do... 



(d) Ash do... 



(e) Organic matter, cd. do. . . 



if) Nitrogen do. . . 



(g) Carbon do . . . 



(A) Hydrogen in organic 



matter do. . . 



(i) Oxygen (by difference) 

 in organic matter, 

 e-if + g + h) do... 



(j) Phosphorus do . . . 



Phosphoric acid (P 2 5 ): 



(k) By fusion do. . . 



(I) By titration do... 



(m) Sulphur do . . . 



(n) Sulphur trioxide 



(S0 3 ) do... 



(o) Total creatinine . . . .do. . . 



(p) Uric acid do . . . 



{q) Chlorine do . . . 



(r) Sodium chloride . . . .do. . . 



(s) Heat of combus- 

 tion calories. 



2264.3 

 2225.81 

 38.49 

 9.96 

 28.53 

 10.29 

 7.47 



1.81 



8.96 

 1.024 



2.345 



.644 



1.608 

 1.250 

 .172 

 1.630 

 2.690 



86 



2966.8 

 2928.23 

 38.57 

 6.23 

 32.34 

 11.97 

 8.31 



2.08 



9.98 

 .830 



1.904 



2.045 



.700 



1.747 



1.200 



.122 



.466 



.769 



98 



2735.2 



2698.27 



36.93 



5.74 



31.19 



11.54 



7.93 



2.19 



9.53 

 .846 



1.938 



1.916 



.712 



1.774 

 .871 



1.082 

 .159 

 .262 



96 



1964.1 



1928.35 



35.75 



6.09 



29.66 



10.39 



7.66 



1.96 



9.65 

 .942 



2.159 



2.107 



.693 



1.729 

 .791 



!.059 

 .356 



.587 



92 



1037.8 



1001.89 



35.91 



6.02 



29.89 



9.98 



7.89 



1.97 



10.05 

 .931 



2.134 



2.178 

 .707 



1.765 



1.110 



1.054 



.408 



.674 



9', 



10,968.2 



10,782.55 



185.65 



34.04 



151.61 



54.17 



39.26 



10.01 



48.17 

 4.573 



10.480 



3.456 



8.623 

 5.222 

 .489 

 3.019 

 4.982 



464 



1 Approximate. The character of the sample precluded an accurate estimation. 



Especially noticeable are the large volumes of urine excreted on the first 4 

 days of the experiment. On the second day there were nearly 3 liters excreted, 

 while on the last day about 1 liter was passed. 



The total amounts of phosphoric acid in the urine as determined both by 

 titration and by fusion are here recorded. The data are of value for discussing 

 the possibility of the presence of so-called organic phosphorus in the urine. 29 



The appearance of the significant paper by Dr. Folin 30 on the relation of 

 creatinine to metabolism led to the determination of creatinine in the urines 

 from this and the succeeding fasting experiments here reported. 



28 For discussion of this subject, see "Organic Phosphorus in Urine,' 

 this report. 

 "Amer. Jour. Physiol. (1905), 13, p. 66. 



Part 



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