300 Influence of Inanition on Metabolism. 



PART 3. DISCUSSION OF RESULTS. 



The data accumulated in the experiments made on fasting men in this 

 laboratory furnish material for a general discussion of the subject of the 

 influence of inanition on metabolism. Of the numerous questions in physiology 

 upon which these results throw light, it will obviously be impossible in this 

 volume to discuss any except those which have more specifically to do with the 

 general subject of metabolism. .Numerous important subjects in metabolism, 

 such as the protein requirement of the body and the relation of the active mass 

 of protoplasmic tissue to the heat production, must be deferred for subsequent 

 discussion. Certain aspects of the influence of inanition on metabolism, 

 however, may with propriety be dealt with now and the following discussion 

 is designed to present all the information thus far obtained regarding the 

 various phases of physiological activity upon which the data throw light. 



Literature. 1 Where reference to the earlier literature on experiments with 

 fasting men is made, the articles given in the following list will be indicated by 

 the number preceding each title, as for example, Luciani (4). 



(1) On the body-weight and urea in a case of starvation. David Nicholson. Brit. 



Med. Journ. (1870), 1, p. 4. 



(2) Metabolism in fasting. A. Sadovyen. Russian Society of General Hygiene 



(1887-1888), 12, pp. 13-76. 



(3) Observations on the metabolism of man during starvation. D. Noel Paton and 



Ralph Stockman. Proceedings of the Royal Society of Edinburgh (1888- 

 1889), 16, p. 121. 



(4) Das Hungern. Luigi Luciani (1890). Leipzig. 



(5) Die Eiweisszersetzung beim Menschen wahrend der ersten Hungertage. W. 



Prausnitz. Zeitschrift f. Biologie (1892), 29, p. 151. 



(6) II ricambio materiale e la tossicita dell' urina nell' inanizione dell' uomo. 



G. Ajello & A. Solaro. La Riforma Medica (1893), Anno ix, 2, p. 542. 



(7) Untersuchungen an zwei hungernden Menschen. Curt Lehmann, Friedrich 



Mueller, Immanuel Munk, H. Senator, N. Zuntz. Archiv f. pathologische 

 Anatomie u. Physiologie u. f. klinische Medicin (1893), 131, Supplementheft. 



(8) Metabolism during fasting in hypnotic sleep. C. F. Hoover and Torald Soil- 



man. Journ. Exper. Med. (1897), 2, p. 403. 



(9) Beitrage zur Kenntniss des Stoffwechsels beim hungernden Menschen. J. E. 



Johansson, E. Landergren, Klas Sonden, und Robert Tigerstedt. Skand. 

 Archiv f. Physiologie (1897), 7, p. 29. 



(10) Beitrage zum Stoffwechsel im Hungerzustande. E. Freund und O. Freund. 

 Wiener klinische Rundschau (1901), 15, pp. 69-71 and 91-93. 



(11) Beobachtungen iiber die Kreatininausscheidung beim Menschen. C. J. C. Van 

 Hoogenhuyze and H. Verploegh. Zeitschrift fur physiologische Chemie (1905), 

 46, p. 415. 



(12) Eiweisszerfall und Acidosis im extremen Hunger mit besonderer Beriick- 

 sichtigung der Stickstoffvertheilung im Harn (nach Untersuchungen an dem 

 Hungerkiinstler Succi). Theodor Brugsch. Zeitschrift f. expt. Pathologie u. 

 Therapie (1905), 1, p. 419. 



1 The excellent article by C. von Noorden on Fasting and Chronic Starvation 

 (Metabolism and Practical Medicine, Vol. II, Pathology, pp. 1-61; Keener & Co., 

 Chicago, 1907) contains much of interest regarding metabolism during inanition. 



