394: 



Influence of Inanition on Metabolism. 



The average total creatinine excreted per kilo of body-weight is 23.2 mg. 

 The lowest observed amount was 17.6 mg. in experiment No. 74 and the 

 highest 27.8 mg., during a 1-day observation in the first nitrogen metabolism 

 experiment. 



Table 206. Total creatinine excreted per day in urine per kilogram of body-weight 

 in metabolism experiments with and without food. 



1 Average of weight at beginning and than underclothes, and deducted from 



end of experiment. weighing of April 14. 



a Average of weighings of first day. 7 Amount for first two days. 



8 Amount for first day. 8 Average weight of April 18-19 less l 



4 Weight at 7 a. m., "March 14. kg. assumed for clothing other than under- 



8 Amount for first day. clothes. 



a Average weight for first two days. One Amount for April 18-19. 

 kg. assumed as weight of clothing other 



In comparing different experiments on the same subject, as, for example, 

 experiments Nos. 73-77 and the two nitrogen metabolism experiments, it is to 

 be noted that in some of them the observations were confined to one day. Aside 

 from the results obtained in experiments Nos. 73 and 74, the uniformity, not 

 only with the same individual in the different experiments, but likewise with 

 different individuals, is very striking. The results here obtained are wholly in 

 accord with those observed by Folin, 67 Closson,* 8 Klercker," and Van Hoogen- 

 huyze & Verploegh (11) in normal individuals. 



In discussing the results of the determinations of creatine and creatinine in 

 the urine of fasting men by the Folin method, the possibility of the presence of 

 other bodies in the urine giving color reactions with sodium picrate must be 



"Amer. Journ. Physiol. (1905), 13, p. 85. 

 "Amer. Journ. Physiol. (1906), 16, p. 252. 

 6 Beitrage zur chem. Physiol, u. Path. (1906), 8, p. 59. 



