Becovery after Inanition. 533 



first day of each experiment, the largest gains of glycogen are accompanied by 

 the smallest losses of protein, while in the 2 instances where glycogen was lost 

 there is a noticeable increase in the loss of protein over the preceding day. 

 It is interesting to note that in some instances where fat was actually lost from 

 the body, there was, nevertheless, a marked gain in glycogen, as, for instance, 

 on the first 2 days of experiment No. 76. On the other hand there was a slight 

 gain of fat on the third day of experiment No. 76 accompanied by a loss of 27 

 grams of glycogen. 



The gains and losses of preformed water underwent marked variations. In 

 experiment No. 70 there was a marked loss on the first 2 days of the experi- 

 ment followed by a gain of 150 grams on the third day. In experiment No. 74 

 there was a gain on all 3 days. In experiment No. 76 there was a loss of 179 

 grams on the first day and a gain of 285 grams on the second. No striking 

 relation appears between the gain or loss of preformed water and the other 

 gains or losses to the body. 



The energy shows an average gain of 74 calories per day in experiment 

 No. 70. In experiment No. 72 the loss was 108 calories. The diet in experi- 

 ment No. 74 was plainly in excess of maintenance since there was an average 

 of 368 calories stored per day. On the other hand, with experiment No. 76 

 the diet was deficient in energy and there was an average loss of 154 calories. 

 Of special interest, perhaps, is the fact that on the first day of experiment 

 No. 76, with a loss of 61 grams of fat and a total loss of 210 calories of energy, 

 there was a positive gain of 134 grams of glycogen. A corresponding observa- 

 tion may be made in connection with experiment No. 72 where there was a 

 marked loss of fat and loss of energy, but nevertheless a gain of glycogen. 



The most noticeable feature of the effect of the ingestion of food following 

 fast is the tendency of the body to restore its depleted glycogen. 



RECOVERY AFTER INANITION. 



Experiments on physiological fasting have been numerous, and yet the 

 problem of the recovery after fast has been but imperfectly studied. The 

 nitrogen metabolism experiments which followed experiments Nos. 76 and 77 

 gave opportunity for a more or less extended study of the degree and rapidity 

 with which the body recovered its equilibrium so far as the nitrogen, phos- 

 phorus, and sulphur were concerned. Data for computing the storage of fat 

 and glycogen are not obtainable after the subject leaves the respiration calo- 

 rimeter, so that aside from general observations regarding the amount of food 

 eaten and the body-weight, there is no direct evidence at hand regarding the 

 gain of fat or glycogen. 



Dietetic habits. The subject of these experiments was of average height 

 and weight (see p. 107), but in recovering from the fasts he consumed liberal 

 amounts of food in proportion to his body-weight and muscular activity. An 



