44 THE VENOM OF HELODERMA. 



not take place, although an extensive desquamation of cells takes place in the 

 tubules and acini of the transplanted glands. 



(4) In the living portions of the transplanted pieces, the regular secretion 

 granules were observed in those pieces which had been removed two, three, and 

 four weeks after transplantation, none being seen in those removed a week 

 after the operation. The transplanted glands retain, however, their toxic prop- 

 erties at all times, as shown by the fact that when pieces of them are used to 

 inoculate mice the latter quickly die; but whether this is due to the venom 

 already present in the gland at the time of transplantation, or to venom newly 

 formed and secreted after transplantation, is not determinable from these 

 experiments. 



(5) Because of the abnormal conditions under which the gland-tissue lives 

 after transplantation, various abnormalities in its structure are found. The 

 number of the typical granules is in every case diminished. Some changes 

 which we observed are probably due to the absence of an effective excretory 

 duct. Thus the collection of desquamated cells or cell detritus in the ducts, 

 the flattening of certain tubule cells, and the dilation of some ducts may be due 

 to this factor. The frequent shrinking of cells and nuclei and the substitution 

 of the typical tubules by clusters of cells markedly differing in their shape from 

 the normal gland cells are results of the abnormal conditions under which cells 

 live after transplantation. 



(6) In the glands from which pieces had been cut no regenerative process 

 could be observed, nor had a noticeable compensatory hypertrophy taken place 

 in the gland of the other side within 4 weeks after the operation. 



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