68 THE VENOM OF HELODERMA. 



The possibility that the local symptoms are due to the effects of micro- 

 organisms which enter the wound either at the time of biting or after the biting 

 can not be excluded, since in our experiments the venom obtained by allowing 

 the helodermas to chew the sponges was not sterilized before injections. 



The following records of autopsies performed on animals which had been 

 injected with heloderma venom show some of the appearances which have 

 been mentioned above: 



Rabbit 13. 



June 26, 2 h 05 received in peritoneal cavity 0.2 c.c. of venom. 5 h 10 dead. 

 Autopsy immediately; lungs, hemorrhagic and edematous; spleen, congestion 

 and hemorrhages; hemorrhagic points in omentum; blood in heart fluid; hemor- 

 rhagic points in stomach; much fluid in small intestine. 

 Rabbit 14, 2 kg. 



June 26, 8 h 05 received subcutaneously 0.4 c.c. of venom. 5 h 40 dead. Au- 

 topsy immediately; lungs congested, hemorrhagic and edematous; ventricles not 

 contracted; small intestine contains much fluid; stomach shows self-digestion. 

 Rabbit 16, 2 kg. 



June 26, 3 h 29 m received subdurally 0.2 c.c. of venom. 5 h 30 dying; killed. Au- 

 topsy immediately; lungs edematous and emphysematous; spleen hemorrhages 

 and congestion; ventricle not contracted; much fluid in small intestine; stomach 

 shows hemorrhages and traces of self-digestion. 

 Rabbit 17, 1890 q. 



June 26, 3 h 57 m received intravenously 0.2 c.c. of venom. 4 h 4^ m dead. 5 h 10 

 autopsy; auricles still beating; lungs hemorrhagic and edematous; ventricle not 

 contracted; small hemorrhages of the stomach. 

 Guinea-pig 105, 2J+0 g. 



June 26, 2 h 40 m received intraperitoneally 0.1 c.c. of venom. 3 h 20 dead. Au- 

 topsy immediately; fluid in intestine slightly increased; hemorrhages in stomach. 

 Guinea-pig 107, 220 g. 



June 26, 2 h 20 m received intraperitoneally 0.05 c.c. of venom. S h 00 m dead. Au- 

 topsy immediately; fluid in intestine slightly increased; hemorrhages in stomach. 

 Guinea-pig 109, 220 g. 



June 26, 2 h 45 m received intraperitoneally 0.02 c.c. of venom. o h 10 m dead. Au- 

 topsy immediately; much fluid in intestine; hemorrhages and self-digested areas 

 in stomach. 

 Guinea-pig 106, 240 g. 



June 26, 2 h 42 m received subcutaneously 0.1 c.c. of venom. S h 20 m dead. Au- 

 topsv; fluid in intestine slightly increased; hemorrhages in stomach. 

 Guinea-pig 10S, 220 g. 



June 26, 2 h 22 received subcutaneously 0.5 c.c. of venom. . h 25 dead. Au- 

 topsy immediately; fluid in intestine considerably increased; hemorrhages in 

 stomach. 

 Guinea-pig 110, 220 g. 



June 26, 2 h 48 m received subcutaneously 0.2 c.c. of venom. 6 h 05 m killed; appeared 

 likely to die before morning. Autopsy immediately ; fluid abundant in intes- 

 tine; hemorrhages and self-digested areas in stomach. 

 Guinea-pig 111, 260 g. 



June 26, 4 h 10 received subcutaneously 0.1 c.c. of venom. J h 20 dying; killed. 

 Autopsy; fluid slightly increased in intestine. 

 Guinea-pig 112, 260 g. 



June 26, 4 h 15 received intraperitoneally 0.1 c.c. of venom. 5 h 10 dead. Au- 

 topsy immediately; fluid slightly increased in intestine; small hemorrhages in 

 stomach. 

 Guinea-pigs 114 and 115 (controls). 



June 26, 6 h 15 from same lot; killed for controls; showed no abnormal fluid content of 

 intestine, no hemorrhages, and no self-digested areas of stomach. 

 Guinea-pig 99, 400 g. 



June 21, 2 h 00 opened abdominal cavity and examined intestines; sewed up wall and 

 injected subcutaneously 0.05 c.c. of venom; no symptoms. 2 h 35 injected 

 0.1 c.c. of venom. 5 h 00 dead. Autopsy; intestines contain much more 

 fluid and gas than at previous examination; hemorrhage in omentum; serous 

 layer of intestine slightly congested; mucous membrane of stomach hemorrhagic; 

 small self-digested areas. 



