GENERAL PROPERTIES AND ACTIONS OF THE VENOM. 



95 



Two rabbits were used in these experiments, the time interval between the 

 first and second injection being 36 days and 44 days, respectively. Although 

 both animals received quite large doses of venom at the second injection, 

 neither of them showed any symptoms as a result of the injection. 



Experiments in anaphylaxis (rabbits). 



In all the experiments (with pigeons, mice, and rabbits), both the first and 

 the second injections were given subcutaneously. It is quite evident that the 

 injection of heloderma venom into an animal does not noticeably increase the 

 susceptibility of the animal to a second dose of venom. 



The venom of Heloderma, therefore, does not cause typical general ana- 

 phylaxis. 



