102 PROCEEDINGS OF THE ACADEMY OF [1893. 



heretofore failed to produce any marked changes. When, however, 

 in the course of my investigations I overloaded the animal system 

 with some of its waste products, Dr. William L. Zuill, M. D., D. 

 V. S., who has kindly carried on the clinical work on animals for 

 our Bacteriological Laboratory, reported in the Times and Register 

 of Sept. 26th, 1891, a reaction by the Amide group on inflamma- 

 tory tissues, the animals experimented on being tuberculous. As 

 this group included that which we believe to produce the inflamma- 

 tion of gout, I was led to review my experience with tuberculosis in 

 relation to lithemia. Studying this field with the lithemic and 

 tuberculous habits in view I was soon impressed with the fact that 

 when these diseased conditions were present at the same time in any 

 individual we could claim it to be an exception to the rule. 



To determine the special action of the Amide group upon 

 inflamed tissues when introduced into the circulation, a case of 

 Lupus vulgaris was selected and first treated by the subcutaneous 

 introduction of .03240 Gm. of Kreatinin, alternated twice weekly 

 with .130 Gm. of Taurin, Urea and Uric acid. The average tem- 

 perature during treatment was slightly raised, though not to any 

 very marked degree, under the influence of such small doses. The 

 more recent patches of Lupus, however, became markedly inflamed, 

 being accompanied with a burning sensation. On the third day 

 after the first injection, a marked granulation could be detected 

 around the outer edge by the aid of a strong amplifying pocket 

 glass. This apparently healthy granulation has continued for ten 

 days, in which time the patch has one half of its original area 

 healed. The result shown at this early stage of the experiment is 

 sufficiently encouraging to warrant not only a continuation of the 

 treatment in this case but in other forms of Tuberculosis. The only 

 other subjects upon which these injections have been tried have been 

 cases of pulmonary tuberculosis in a very advanced stage, where 

 there was too much lung-tissue already destroyed to warrant the 

 expectation of a favorable result. The fact that we apparently 

 have an action on the Lupus and no marked result with small 

 doses on advanced cases of pulmonary tuberculosis causes me to 

 realize that the line of experimentation must not be confined to 

 tuberculous inflammation but extended to the action of these 

 organic substances on the entire group of inflammatory growths, 

 the effect being produced, possibly, by supplying that in which the 

 pathological tissues are deficient. This line of inquiry, which had 



