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of atoxyl, there is later likely to be a recrudescence; and it was foi 

 this reason that two chemists at Liverpool, Professor Benjamin Moore 

 and Dr. Nierenstein, conducted still further research for a better 

 remedy. These men found that although atoxyl killed most of the 

 organisms, a resistant form was able to withstand the action of the 

 drug. A second remedy was then given during this resistant stage, 

 and success seemed assured. The disease may continue for many 

 years, however, so it is too early to know how effective the double 

 remedy is in man. 



It is interesting to observe that as in malaria the complete life- 

 cycle of the parasite was first followed in bird malaria; so in sleeping 



Croftox Lodge, University of Liverpool. 



sickness what is apparently the complete cycle has been worked out in 

 trypanosome infection of the frog. It was observed by Dutton in the 

 Congo that the frog trypanosome undergoes another cycle of develop- 

 ment outside the frog; and the recent experiments of Kleine in Ger- 

 man East Africa seem to point to another cycle of development of the 

 trypanosome of man in the tsetse fly. Thus the study of infections 

 in lower animals may be of the greatest assistance in solving the prob- 

 lems of disease in man. 



The other of these two diseases of Central Africa is tick fever. 

 This infection was first described by Dr. Livingstone, the famous 

 explorer, who found the disease in Portuguese South Africa, and at- 

 tributed it to the bite of a tick. The discovery that spirochetes could 

 be found in the blood of every patient ill with tick fever was first 

 published by P. H. Eoss and Milne, though there has been some doubt 

 whether their work antedated that of Dutton. However, Dutton was 



