382 PROCEEDINGS OF THE ACADEMY OP 



I tied the abdominal aorta and then gave conia to twenty-seven 

 other frogs, and always obtained results similar to those obtained 

 in Experiment 36. In the two following experiments the sciatic 

 nerve of one side was cut, while the main artery of the other hind 

 leg was tied ; so soon as anterior paralysis occurred the peri- 

 pheral end of the cut sciatic ceased to respond when galvanism 

 was applied, while on the ligatured side the sciatic when irritated 

 caused contractions until long after death. 



Exp. 37. Tied the left popliteal arteiy and cut the right sciatic 

 nerve of a frog. Both sciatics respond equally well to galvanism. 

 3.09, injected one-quarter drop of conia beneath skin of the back. 

 3.1*7, paralysis complete, excepting the left leg. 3.18, galvanized 

 the peripheral end of the right sciatic without producing any con- 

 tractions, while galvanism applied to the left sciatic causes con- 

 tractions in its tributary muscles. 



Exp. 38. Another frog was treated in exactly the same manner 

 and gave identical results. After paralysis had occurred in the 

 two uninjured extremities, galvanism was applied to the cut sciatic 

 with no effect, and then to the sciatic isolated from the poison by 

 ligature of the main artery, producing contractions in its tributary 

 muscles. 



In the two following experiments I separated in frogs all the 

 tissues at the upper part of one of the thighs except the nerve ; 

 conia was then given, and after paralysis had occurred this nerve 

 continued to respond to irritants, while the nerve on the opposite 

 side refused to conduct impressions. 



Exp. 39. Separated in a frog all the tissues at the upper part of 

 the left thigh, except the nerve. 2.13, poisoned the animal with 

 one-twentieth drop of conia. 2.21, paralysis complete in all por- 

 tions of the body to which the poison has access ; after galvanic 

 stimulation of the right sciatic and of the median nerves failed to 

 excite contractions in the tributary muscles, the left leg responded 

 not only to irritation applied to its nerve, but also to galvanic 

 stimulation applied to other portions of the body. 



Exp. 40. Repeated the last experiment with similar results. 



These experiments show that when the direct access of the 

 poison to a limb is prevented, that limb never becomes paralyzed ; 

 thus proving that the paralysis must be due to the action on the 

 efferent or motor nerves. 



If any further proof be wanted of this action of conia on the 



