NATURAL SCIENCES OF PHILADELPHIA. 



385 



medium-sized frog. 2.49, injected one-eighth drop of conia into 

 the abdomen. 2.58, the right fore leg is paralyzed, the rest of the 

 extremities move freely. One pole of a galvanic battery on the 

 spinal cord and the other on the left fore leg causes reflex move- 

 ments in the hind legs, while with the same pole on the spine and 

 the other on the right fore leg, the same current being applied, no 

 reflex movements occurred. 



Exps. 47 and 48. Repeated the last experiment with similar 

 results. 



These experiments not only prove that sensation is impaired, 

 but, as this impairment did not occur in the ligatured anterior 

 extremity and was very manifest in the uninjured extremity, it 

 must have been due to the action of the drug on the periphery of 

 the afferent or sensory nerves. 



In opposition to these conclusions could be cited all investiga- 

 tors on hemlock since the time of Christison, but as I have yet to 

 find the first paper in which efforts have been made to prove that 

 loss of sensation does not occur, but little importance can be 

 attached to such assertions. 



Action on the Circulatory System. On the Pulse. As is shown 

 by the following experiments, conia, in ordinary therapeutic 

 doses, causes an increase in the number of heart beats, with a 

 subsequent decrease, but in these doses the disease never goes 

 below the original number of beats. 



