112 



STUDIES ON PATHOLOGIC OVA. 



embryo be found. A portion of mucous membrane of the 

 uterus is attached to the chorion. This shows marked 

 inflammatory infiltrations and fibrosis. 



(5) The villi of the chorion are swollen, show marked 

 mucoid degeneration, and the stroma of many of them has 

 undergone a kind of coagulation necrosis. The stroma is 

 non-vascular and Hofbauer cells are common. The 

 trophoblast cells are generally normal in appearance. 

 There are many leucocytes, especially within the decidua, 

 considerable areas of which are purulent. Except for 

 relatively small regions, the chorionic membrane, although 

 devoid of endothelium and disintegrated in places, is but 

 slightly invaded, in spite of the fact that it is surrounded 

 in part by a narrow zone of leucocytes. 



(6) Marked infiltration and hydatiform degeneration. 



No. 173. 



(1) L. R. Jump, Tesla, California. 



(2) A 25X15X10 mm. 



(3) Marriage December 15, 1899; last menstrual period 

 December 20; abortion February 12. Several other masses 

 about the same size, which appeared to be composed of 

 blood-clots, were passed at this time. 



(5) Upon section the specimen was found to be com- 

 posed of a collapsed ovum well covered with villi. The 

 chorionic membrane is almost wholly destroyed. Within 

 the cavity of the cffilom there is an irregular, ill-defined 

 mass of blood-clot. The small sclerotic fragments of 

 accompanying decidua are markedly infiltrated. 



(6) Severe infiltration; early hydatiform degeneration. 



No. 181. 



(1) D. S. Lamb, Washington, District of Columbia. 



(2) A 18X18X10 mm. 



(4) The ovum is filled with reticular and granular 

 magma, and no remnants of an embryo could be found, 

 although every particle which might contain it, with the 

 adjoining chorion, was cut into serial sections. 



(5) The mesoderm of the chorion and villi is edematous 

 and shows mucoid degeneration. The epithelial covering 

 is poorly developed, often being composed of but one layer 

 of cells. 



(6) Decidua absent. 



No. 185. 



(1) F. R. Sabin, Baltimore, Maryland. 



(2) A 40X25X15 mm. 



(3) The abortion occurred seven weeks after the begin- 

 ning of the last menstrual period. 



(4) The specimen was brought to the laboratory in 

 formalin. Upon opening, it was found that the ccelom 

 was filled with reticular and granular magma. No trace 

 of an embryo could be found, although the entire ovum 

 was cut into serial sections. 



(5) The main wall of the chorion is decidedly thickened 

 and completely filled with leucocytes with nuclei in all 

 stages of fragmentation. They form a fairly sharp border 

 on the ccelom side, making the chorion appear as the wall 

 of an abscess. The leucocytic invasion must have been 

 merely from the ccelom side, for the villi are not affected 

 to any extent. Some of them are edematous; others show 

 marked mucoid degeneration. 



(6) Severe infiltration of the decidua and infection of the 

 chorionic vesicle. 



No. 190. 



(1) C. M. Ellis, Elkton, Maryland. 



(2) A 25X22X12 mm. 



(4) The ovum is filled with magma, within which no 

 trace of an embryo can be found, although the entire 

 specimen was stained and cut into serial sections. 



(5) The chorion and villi are apparently normal, except 

 for slight maceration and hydropic degeneration. Some 

 villi contain blood-vessels. 



(6) Decidua absent. 



No. 191. 



(1) C. M. Ellis, Elkton, Maryland. 



(2) A 16X11X11 mm. 



(3) The specimen is from a supposedly induced abortion, 

 and had been in Dr. Ellis's collection for 10 years before it 

 was sent to us. 



(4) The cavity of the spceimen is filled with a small 

 amount of granular magma, and the villi are matted. No. 

 embryo was found. 



(5) The chorionic wall is somewhat fibrous, as are also 

 the cores of the villi. The trophoblast may be normal, and 

 there is no indication of surrounding inflammation. 



(6) Probably macerated, induced. Decidua absent. 



No. 195. 



(1) D. S. Lamb, Washington, District of Columbia. 



(2) A 30X30X30 mm. 



(4) The specimen was well covered with villi and con- 

 tained some reticular magma. No embryo could be 

 found, although the entire ovum was cut into sections. 

 The mesoderm of the chorion appears normal and is rich 

 in blood-vessels filled with blood, but that of the villi is 

 non-vascular and rather clear. 



(6) Dedicua not included. 



No. 204. 



(1) D. S. Lamb, Washington, District of Columbia. 



(2) A 14X12X8 mm. 



(4) The specimen, said to be three weeks old, was found 

 filled with a mass of granular magma. 



(5) The whole ovum was stained and cut, but no trace 

 of an embryo could be found. The chorion and villi 

 appear normal. 



(6) Decidua not included. 



No. 233. 



(1) W. P. Miller, Hagerstown, Maryland. 



(2) A 70X45X40 mm. 



(4) The irregular mass appears to be an ovum filled 

 with blood. 



(5) Sections, however, show that there is a mixture of 

 distorted villi, blood, syncytium, decidua, and pus. Most 

 of the villi are completely degenerate, their place being 

 occupied by detritus mixed with leucocytes. The decidua 

 shows marked infiltration and fibrosis. 



(6) Severe infiltration. 



No. 243. 



(1) Max Brodel, Baltimore, Maryland. 



(2) A 30X20X10 mm. 



(4) The specimen is pear-shaped, with smooth, thin 

 walls, over which are scattered a few thin villi. 



(5) The latter and the chorionic membranes show 

 maceration changes. 



(6) Normal macerated. Decidua absent. 



No. 255. 



(1) Max Brodel, Baltimore, Maryland. 



(2) A 20X20X10 mm. 



(5) The villi are matted; some are fibrous, but others 

 mucoid. At points the syncytial layer is well mixed with 

 leucocytes, which also have invaded some of the villi as 

 well as the mesoderm of the non-vascular chorion. The 

 whole chorion was cut into serial sections, but no trace of 

 an embryo or remnants of amnion were found. 



(6) Infected. Decidua not included. 



No. 278. 



(1) E. M. Stanton, Albany, New York. 



(2) A 6X4 mm. 



(3) This specimen was found accidentaljy in curettings 

 from a woman supposed to have chronic endometritis 

 following pregnancy. There is nothing in the history by 

 which the age of the specimen could be estimated. Before 



